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Chloroformum

T. F. Allen - Εγκυκλοπαίδεια της Καθαρής Materia Medica (φάρμακα που απουσιάζουν από τα άλλα βιβλία) · Timothy Field Allen · 21,274 χαρακτήρες

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General EN

Formula , CHCl 3 .

Preparation , for internal administration, solutions in alcohol.

Authorities. 1 , Lembke, provings with repeated doses of 1 to 22 drops, A. H. Z., 39; p. 369; 2 , Dr. Board, effects of 4 ounces internally, Br.

Med. J., 1866; 3 , Dr. Busey, effects of a teaspoonful internally, Am. J. of Med.

Sc., Oct. 1872; 4 , Chereau, effects of 37 1/2 drachms, Med. Times and Gaz., 1857; 5 , Dowling, effects of 1 1/2 ounces, B. and F. Med.-Chir. Rev., July, 1864; 6 , Dunereicher, effects of inhalation, Lond.

Ed. M. J. of M. Sc., 19, 372; 7 , Fricke, effects of a tablespoonful internally, Phil.

Med. Times, May, 1871; 8 , Haffoldt, chronic effects of habitual inhalation by an asthmatic patient, L'Art Méd., 6, 378; 9 , Hammond, inhalation, fatal, Med. T. and Gaz., 17, 174, n. s.; 10 , Lamm, fatal case of drinking considerable for sleeplessness, A. H.

Z. (M. B.), 5, 42; 11 , Langenbeck, inhalation, Deutsche Klin., 48; 12 , Mackei, effect of 12 1/2 drachms internally, Union. Med., 1864; 13 , Richet, fatal inhalation, Med Times and Gaz., 18, 142; 14 , C.

H. Smith, 2 ounces internally, Am. J. M.

Sc., Oct. 1857; 15 , Spence, 2 ounces internally, Lancet, Aug. 1856; 16 , Yvonneau, general effects, Hirschel's Archiv., 1, 158; 17 , Holmes, effects of 3 1/2 ounces, Assoc. Journ., 1856; 18 , Journ. de Toul., 1857, a woman swallowed 2 ounces; 19 , Pringle, effects of 2 ounces internally, Lancet, 1856; 20 , Robert, Gaz. des Hôp, 1853; 21 , Santesson, inhalation, Hygeia, 2, 599; 22 , effects of inhaling for extraction of tooth, All. Med. Zeit.

(from Am. Obs., 7, 528); 23 , Berridge, effects of inhalation, M. H. Rev., 16, 38.

Mind EN

Emotional.

Wild excitement, followed by complete insensibility, [17] .

On waking from its effects she felt almost tipsy, frequently laughing, and not understanding what she said or did, [23] .

Laughed and talked; told how the medicine burnt her tongue and hurt her (after half an hour), [3] .

Talked nonsense, but spoke grammatically, [23] .

In two provers obscene language was used under its influence, [23] .

In two cases they sung comic songs, and one addressed the surgeon in a most familiar manner, [23] .

Afterwards she could scarcely be persuaded to leave the piano, of which she was very fond; she would have continued playing all night if permitted; she could scarcely be persuaded to go to bed, [23] .

Intellectual.

Seemed scarcely to understand anything said to him, and kept on muttering, [2] .

The patient pronounced some incoherent words, and sought to get away from the chloroform, [13] . [10.] Insensible, still continuing to vomit (soon after), [12] .

Could not be roused from insensibility (after ten minutes), [14] .

Remained unconscious for ten hours, and felt no uneasiness on awaking, [8] .

Entirely unconscious (after eight minutes), [7] .

Lying in a state of perfect unconsciousness (apparently in a profound sleep), from which she could not be roused (after twenty minutes), [15] .

Complete unconsciousness, [19] .

Utter loss of consciousness, [12] .

Vertigo EN

Sensation of vertigo rising from the spine into the occiput (fourth day), [1] .

Vertigo, [16] .

Dizziness, [7] . [20.]

Whirling of the head; sensation as if he would fall forward (second day), [1] .

Sensation as if the ground were waving, on closing the eyes (third day), [1] .

General Head.

Empty feeling in the head (fourth day), [1] .

The head is light, with a peculiar sensation of clearness (first day), [1] .

Heaviness of the head (fourth and fifth days), [1] .

Heaviness in the head and pain in the forehead (sixth day), [1] .

Felt a rush of something to the head, [7] .

Headache, [16] .

Violent headache (after sixteen hours), [16] .

Pressure in various places in the brain (fifth day), [1] . [30.] Pressure in various parts of the brain (sixth day), [1] .

Temples.

Pressing in the temples (fifth day), [1] .

Pressure upon the temples (second day), [1] .

Occiput.

Heaviness of the occiput (fourth day), [1] .

Heaviness in the occiput, with vertigo (fifth day), [1] .

EYE.

Lids.

Inclination to close the eyes (fourth day), [1] .

Eyes closed involuntarily (fifth day), [1] .

The eyes close in spite of one (fourth day), [1] . Lachrymal Apparatus.

Moisture of the eyes (third day), [1] .

Moisture, almost lachrymation of the eyes (third day), [1] .

Conjunctiva. [40.] Conjunctivae injected, [13] .

Conjunctiva quite insensible (after twenty minutes), [15] .

Ball.

The eyes were suddenly turned up, [9] .

Eyes fixed towards upper and inner angle, [5] .

Pupil.

Pupils dilated (third day), [1] .

Pupils dilated (just before death), [20] .

Pupils dilated and insensible, [5] , [11] , [16] .

Pupils widely dilated and insensible, [4] .

Pupils very much dilated, [2] .

Pupils enormously dilated, [12] . [50.]

Pupils very large (third day), [1] .

Pupils contracted (second day), [1] .

Pupils at first contracted (soon), (fifth day), [1] .

Pupils very much contracted (after twenty minutes), [15] .

Pupils greatly contracted, [18] , [19] .

Pupils variable, now dilated, now contracted, [17] .

Pupils during narcosis dilated; afterward, before death, contracted, [10] .

Vision.

Everything seemed more distinct than usual (immediately), [1] .

Dimness before the eyes (sixth day), [1] .

Darkness before the eyes (fourth day), [1] . [60.]

All seemed to grow dark except one bright spot, [23] .

The sight gradually went during inhalation till everything seemed quite dark; it returned gradually , [23] .

Dark points and bright streaks before the eyes (fourth day), [1] .

Small black points float before the eyes (third day), [1] .

Dark spots before the eyes, with bright spots on closing them (fourth day), [1] .

Large black spots before the eyes (second day), [1] . A number of small gray spots and linear bodies appear to float a few inches before the eye; while looking at a distance they follow the motion of the eye; the same appearance before each eye separately (third day), [1] .

Numerous bright points before the eyes, with great inclination to close the eyes, and much yawning (fourth day), [1] .

Bright and dark points; white flames when the eyes are closed, or when looking at a dark background (fifth day), [1] .

Bright and dark spots before the eyes (sixth day after fifteen minutes), [1] . [70.]

Flickering before the eyes (fifth day), [1] . Sparks before the eyes, [16] .

Flashes of light before the eyes, [7] .

Ear. Ears seemed stopped with cotton (fifth day), [1] .

Ringing in the ears (fifth day), [1] , [16] . Roaring in the ears (sixth day), [1] .

Roaring in the ears like boiling water (fifth day), [1] .

Nose EN

Objective.

Nostrils obstructed by swelling of the mucous membrane, [8] .

Bleeding from the left nostril a teaspoonful of dark blood; if afterwards bleeds easily (fifth day), [1] .

Smell.

Sense of smell is weaker than usual (third day), [1] . [80.] Entire loss of smell (lasted two months), [8] .

Face EN

Cadaverous countenance, [4] , [12] .

Expression that of a person partially intoxicated (after half an hour), [3] .

Some flushing of the face, [9] .

Face flushed, [13] .

Face livid, [6] ;

(after two hours), [11] , [19] .

Face became turgid, [9] .

Trismus, [6] .

Teeth EN

Teeth smooth, as after acids (fourth day), [1] .

Tongue.

Tongue pale, [8] . [90.] Tongue covered with frothy saliva (third day), [1] .

Tongue dry and parchment-like, [4] .

General Mouth.

Mouth half open, [4] .

Mucous membrane of mouth and throat flaccid and swollen, [8] .

Foamed at the mouth, [6] .

Complained of the burning sensation the dose produced (immediately), [7] .

Complained of the pungency of the medicine, [3] .

Saliva.

Much saliva (second day), [1] .

Thin saliva (fourth day), [1] .

Taste EN

Soapy taste in the mouth (third day), [1] . [100.] Altered taste of all food and drink, especially coffee (lasted two months), [8] .

Sense of taste abolished, [8] .

Speech.

Could hardly articulate, [2] .

Throat EN

Jugular veins distended, [4] , [11] .

Scraping and dryness in the throat (second day), [1] . Prickling sticking in the throat, especially on swallowing (soon), (second day), [1] .

Fauces.

Fauces very red, with scraping in them (fourth day), [1] .

Violent burning in the fauces and heat in the stomach (immediately after 20 drops), (sixth day), [1] .

Scraping in the fauces (third day), [1] .

Violent scraping and coldness in the fauces, on inspiration (fifth day), (soon after taking), [1] .

Swallowing. [110.] Deglutition interrupted, slow, and difficult, [3] .

Stomach EN

Thirst. Thirst (second day), [18] .

Great thirst at first, [11] .

Eructation and Hiccough.

Eructations tasting ethereal, [1] .

Frequent eructations smelling strongly of chloroform, and causing prickling in the nose (fourth day), [1] .

Constant hiccough, [17] .

Nausea and Vomiting.

Nausea (sixth day), [1] ;

(second day), [18] .

Nausea, with much saliva (fifth day), [1] .

Urging to vomit (fifth day), [1] . Vomiting, [9] . [120.] Vomiting (soon after), [12] , [14] .

Violent vomiting, [17] .

Stomach EN

Pain in the epigastrium (during convalescence), [19] .

Severe pain about region of stomach and spleen, [5] .

Burning in stomach, [3] .

Burning in the stomach alternating with chilliness (fifth day), [1] . Pressure in the stomach (third day), [1] .

Pressure in the stomach, increased by external pressure (third day), [1] . Pressure in the stomach, with nausea (fifth day), [1] .

Dull pressure in the stomach (third day), [1] .

Abdomen EN

Objective. [130.] Abdomen tense (before death), [10] .

Rumbling, with passage of flatus (fifth day), [1] .

Rumbling in the abdomen (fourth day), [1] .

Rumbling in the abdomen, with passage of flatus (third day), [1] .

Much rumbling in the abdomen, with warmth (third day), [1] .

Passage of much flatus (third day), [1] .

Abdomen painful (second day), [18] . Cuttings deep from the stomach to the navel (second day), [1] .

Rectum And Anus. Although the rectum and intestines were as torpid as the genital organs, yet the sphincter ani preserved its contractility, [8] .

Stool EN

Diarrhoea.

Bloody diarrhoea (during convalescence), [19] . [140.] On two occasions, I have noticed involuntary discharge of faeces, [23] .

Much blood in the stools (second day), [18] .

Constipation.

Constipation sometimes lasted eight days, but without giving rise to uneasiness, [8] . The torpidity of the large intestine was such that he was obliged to resort continually to cathartics, [8] .

Urinary Organs EN

Urethra.

Emission of urine painless, but accompanied with a curious sensation along the urethra, [8] .

Stitches in the urethra (fifth day), [1] .

Voluptuous tickling at the orifice of the urethra, with erections and desire to urinate (fourth day), [1] .

Much desire to urinate (fourth day), [1] .

Micturition. Urine increased in quantity (third and fourth day), [1] .

Bladder distended, and bedclothes stained by urine that had escaped, [4] . [150.]

When the bladder was distended, the urine was only expelled after much effort, [8] . Urine suppressed, [10] .

Urine EN

Urine dark yellow (fourth day), [1] . Specific gravity of urine rather lower than normal; it contained a large proportion of triple phosphates, and traces of uric acid crystals, [8] .

Sexual Organs EN

Genitals as if much shrivelled (third day), [1] .

On one occasion erection of the penis occurred, [23] .

No erections for two months, [8] .

Sexual desire, with a peculiar feeling in the testicles, which made him believe that the spermatic secretion still continued, and that the impotence was owing to paralysis of the perineal muscles, [8] .

Sexual appetite wanting, and the generative functions in a languid state, for several weeks, [8] .

Respiratory Organs.

Tracheal râle, [12] .

He spoke in an altered drawling voice, [23] . [160.] Loss of power of speech; could not utter any sound whatever; remained in that state for five weeks, after which she began to speak in a low tone, [22] .

Respiration stertorous, [12] ;

(after ten minutes), [14] , [16] .

Breath smelt of chloroform, [5] .

Short, quick, irregular, and superficial breathing, [3] .

Breathing slow and stertorous, [5] . Respiration became very slow (2), and stertorous, [19] .

Respiration very slow and deep (sixth day), [1] .

Respiration became very slow, full, and deep, [21] .

Respiration very slow and difficult, [11] .

Respiration very slow, with plainly perceptible beating of the heart internally (fourth day), [1] . [170.] Respiration 15 (usually 22), (soon), (sixth day), [1] . Respiration fell to two in a minute, [18] .

Deep, slow respiration (after one hour); respiration very slow, fifteen to the minute, superficial, with at times deep inspiration (after one hour and a quarter), (fifth day), [1] . Frequent deep breathing (fifth day), [1] .

Respiration during narcosis feeble and slow, afterward before death it became rapid, deep, and rattling, [10] .

Irregular respirations, [6] .

Respirations sometimes irregular and short, at others deeper and separated by longer intervals, [4] .

Some oppression of breathing, [5] .

Respiration appears embarrassed, [5] .

Respiration arrested every now and then, [12] . [180.]

Eight or ten inspirations were distinctly remarked after the complete and entire cessation of the cardiac movements, [13] .

Chest EN

Slow, but regular, heaving of the chest, with some subsultus of the muscles, [4] .

Moist crepitation over lungs, [5] .

Tension in the chest and bruised feelings in the joints (fourth day), [1] .

Oppression of the chest, with slow respiration for a long time (fifth day), [1] .

Sternum.

Pain in the right margin of the sternum, deeply seated (fourth day), [1] .

Pressure behind the sternum (fifth day), [1] .

Heart And Pulse. Praecordium.

Pressure on the heart (sixth day), [1] . Stitches in the region of the heart and upper half of the left lung (sixth day), [1] .

Internal pulsation of the heart, like a trembling, rather more while sitting, with oppression of the chest, nearly the whole day (fifth day), [1] .

Heart's Action. [190.] Action of heart occasionally tumultuous, [12] .

Beating of the heart powerful, rapid, felt through the whole chest into the arms, and moving the book held in the right hand (first day), [1] .

Beating of the heart felt in the chest without being noticed in the hand (fourth day), [1] .

Heart beat so feebly that it required sustained attention to perceive its weak and rare contractions, [4] .

Heart-sounds feeble, [5] .

Pulse EN

Pulse frequent and undulating, [6] . Pulse rapid and weak, [17] .

Pulse more rapid than usual (immediately), [1] .

Pulse at first increased, afterwards small and indistinct, [11] .

Pulse 78, soft and tolerably full (after twenty minutes), [15] . [200.] Pulse 100 and feeble; afterwards insensible, [12] .

Pulse 100 to 120, soft (second day), [18] .

Pulse slower than normal (at first), [21] .

Pulse became slower, and suddenly stopped, [21] .

Pulse 64, usually 75 (third day), [1] .

Pulse about 60 (after ten minutes), [14] .

Pulse 60 (after half an hour), (fourth day), [1] .

Pulse 56 (after one hour), (fourth day), [1] .

Pulse 50, very weak, [16] .

Pulse weak and slow, afterwards, just before death, it became full and strong; then rapid (160), and weak, [10] . [210.]

Pulse 95 (after ten minutes); 65 (after half an hour); 70 (after three-quarters of an hour); 54 (after one hour and a quarter); 66 (after two hours and a half), [1] .

Pulse 63, irregular; before the proving 70 to 75 (fifteen minutes after 12 drops), (fourth day), [1] . Pulse soon after taking small, irregular, scarcely perceptible, 80; after a few minutes 85, regular; after half an hour 70, for several beats in succession; then again some very slow beats; 62 (after three-quarters of an hour), firm; 64 (after one hour); 58 (after one hour and a half); 70 (after two hours and a half), (fifth day), [1] .

Pulse very irregular, at one time very slow, then soon again rapid beats in quick succession (second day), [1] .

Pulse small (third day, three-quarters of an hour after 8 drops), [1] .

Pulse small and fast failing, [5] . Pulse became very weak, [19] .

Almost imperceptible pulse, [3] .

Almost pulseless, [2] .

Pulse suddenly ceased, face became pale, [20] . [220.] Pulse, from beating at the rate of 100, stopped as if it had been struck with lightning, [9] .

Neck And Back. Veins of neck swollen, [13] .

Dull pains in the region of the kidneys (second day), [18] .

Extremities In General.

Objective.

During commencing anaesthesia, twitching of the muscles of the extremities, especially of the arms, [21] .

Cracking in the joints and loss of power in them, on moving (fifth day), [1] .

Excessive weakness in the limbs (fourth day), [1] .

Complete resolution of the limbs, [12] .

Subjective.

Compressed sensation in the right ankle and left elbow (second day), [1] .

Bruised pain in the shoulder and ankle-joints (third day), [1] .

Feels very much bruised in all the limbs (sixth day), [1] .

Superior Extremities. [230.]

Bruised sensation in the arms (fifth day), [1] .

Forearm.

Pressing pain in the muscles of the right forearm and in the flesh above the hollow of the right knee (second day), [1] .

Hand.

Peculiar unsteadiness of the hands, with sensation of prostration (second day), [1] .

Fingers.

Finger-nails blue (fourth day), [1] .

Fingers convulsively pressed against the palms of the hands, leaving impressions of the nails, [4] .

Inferior Extremities.

Staggered in walking (after half an hour), [3] .

Constant painful weakness in the whole left leg, especially the lower leg and calf (first day), [1] .

Great weakness in the feet (fifth day), [1] .

Generalities EN

Objective.

Great nervous excitement, [16] . The muscles stiffened, [13] . [240.] Muscles become relaxed, [9] .

Frequent stretching and yawning (fifth day), [1] . Very feeble, [7] . Every exertion of the muscles fatigues very soon (third day), [1] . Restless and tossing about before death, [10] . Subjective. Anaesthesia, with muscular resolution, [13] . Absolute general anaesthesia, [12] .

Complete loss of sensibility and recognition, but not of self-consciousness. (Hirschell), [11] . Sense of touch perverted, [8] .

When under its influence, felt extremely comfortable; could have remained as she was forever, [23] .

She felt as if floating on wings, [23] . [250.] Excessive weariness in all the joints, especially the ankles (third day), [1] .

Sensation as if the seat were tottering (fifth day), [1] . While sitting, a sensation as if the chair and table were moving in different directions (third day), [1] . Felt queer twitchings in her body, which lasted over twenty-four hours, [7] .

Felt as if hammers were beating all over her, [23] .

Skin EN

Skin very blue, with coldness of the eyes (fourth day), [1] . Tingling of the limbs, [7] .

Crawling in the left fingers (first day), [1] .

Sleep And Dreams. Yawning (fourth day), [1] .

Much yawning and closing of the eyes, even while walking (sixth day), [1] . [260.]

Excessive yawning, as though he would dislocate the jaw (third day), [1] . Great sleepiness and much yawning (fourth day), [1] .

A very agreeable sensation of sleepiness, with a very quiet mood (fourth day), [1] .

Very sleepy, with chilliness and cold extremities (sixth day), [1] .

Much sleep (fourth day), [1] .

Apparently deep unconscious sleep, from which she could not be awakened, [18] .

Comatose sleep, [16] .

After vomiting had been induced, sank quickly and suddenly into a profound and alarming coma, characterized by excessive pallor of the features, sunken eyes, contracted pupils, insensibility of the cornea, perfect and universal muscular relaxation, complete anaesthesia, coldness of the extremities, [3] .

Fever EN

Chilliness.

Skin cold, pale, [16] .

Cold skin, especially on the extremities, with chilliness in the back, during the whole proving, [1] . [270.] Surface of body cold and clammy, [5] .

Constant chilliness, with cold extremities (third day), [1] .

Internal chilliness (fourth day), [1] . Much internal chilliness, with cold skin (fifth day), [1] .

Very cold, [2] .

Temperature during narcosis diminished, but before death increased, [10] .

Chilliness deep in the back, extending to the temples (sixth day), [1] .

Great coldness in the innermost portion of the spine, with coldness and paleness (after one hour and a half), (fourth day), [1] .

Extremities cool, [11] .

Heat.

Feverish excitement (after sixteen hours), [16] . [280.] Heat in the head (sixth day), [1] .

Head hot, [11] .

Heat in the occiput (fifth day), [1] .

Warmth in the stomach (fourth day), [1] .

Sensation of warmth in the bronchi that increases to a biting-burning, with a very troublesome constriction of the larynx, and with difficult interrupted sighing respiration, even amounting to a suffocative anxiety, [16] .

Sweat.

Sweat copious before death, [10] .

Aggravation EN

( On closing eyes ), Sensation in head.

( On inspiration ), Scraping, etc., in fauces.

( External pressure ), Pressure in stomach.

( Sitting ), Pulsation of heart.

Amelioration EN

( Brandy ), The symptoms.