Chloroformum
T. F. Allen - Εγκυκλοπαίδεια της Καθαρής Materia Medica (φάρμακα που απουσιάζουν από τα άλλα βιβλία) · Timothy Field Allen · 21,274 χαρακτήρες
General EN
Formula , CHCl 3 .
Preparation , for internal administration, solutions in alcohol.
Authorities. 1 , Lembke, provings with repeated doses of 1 to 22 drops, A. H. Z., 39; p. 369; 2 , Dr. Board, effects of 4 ounces internally, Br.
Med. J., 1866; 3 , Dr. Busey, effects of a teaspoonful internally, Am. J. of Med.
Sc., Oct. 1872; 4 , Chereau, effects of 37 1/2 drachms, Med. Times and Gaz., 1857; 5 , Dowling, effects of 1 1/2 ounces, B. and F. Med.-Chir. Rev., July, 1864; 6 , Dunereicher, effects of inhalation, Lond.
Ed. M. J. of M. Sc., 19, 372; 7 , Fricke, effects of a tablespoonful internally, Phil.
Med. Times, May, 1871; 8 , Haffoldt, chronic effects of habitual inhalation by an asthmatic patient, L'Art Méd., 6, 378; 9 , Hammond, inhalation, fatal, Med. T. and Gaz., 17, 174, n. s.; 10 , Lamm, fatal case of drinking considerable for sleeplessness, A. H.
Z. (M. B.), 5, 42; 11 , Langenbeck, inhalation, Deutsche Klin., 48; 12 , Mackei, effect of 12 1/2 drachms internally, Union. Med., 1864; 13 , Richet, fatal inhalation, Med Times and Gaz., 18, 142; 14 , C.
H. Smith, 2 ounces internally, Am. J. M.
Sc., Oct. 1857; 15 , Spence, 2 ounces internally, Lancet, Aug. 1856; 16 , Yvonneau, general effects, Hirschel's Archiv., 1, 158; 17 , Holmes, effects of 3 1/2 ounces, Assoc. Journ., 1856; 18 , Journ. de Toul., 1857, a woman swallowed 2 ounces; 19 , Pringle, effects of 2 ounces internally, Lancet, 1856; 20 , Robert, Gaz. des Hôp, 1853; 21 , Santesson, inhalation, Hygeia, 2, 599; 22 , effects of inhaling for extraction of tooth, All. Med. Zeit.
(from Am. Obs., 7, 528); 23 , Berridge, effects of inhalation, M. H. Rev., 16, 38.
Mind EN
Emotional.
Wild excitement, followed by complete insensibility, [17] .
On waking from its effects she felt almost tipsy, frequently laughing, and not understanding what she said or did, [23] .
Laughed and talked; told how the medicine burnt her tongue and hurt her (after half an hour), [3] .
Talked nonsense, but spoke grammatically, [23] .
In two provers obscene language was used under its influence, [23] .
In two cases they sung comic songs, and one addressed the surgeon in a most familiar manner, [23] .
Afterwards she could scarcely be persuaded to leave the piano, of which she was very fond; she would have continued playing all night if permitted; she could scarcely be persuaded to go to bed, [23] .
Intellectual.
Seemed scarcely to understand anything said to him, and kept on muttering, [2] .
The patient pronounced some incoherent words, and sought to get away from the chloroform, [13] . [10.] Insensible, still continuing to vomit (soon after), [12] .
Could not be roused from insensibility (after ten minutes), [14] .
Remained unconscious for ten hours, and felt no uneasiness on awaking, [8] .
Entirely unconscious (after eight minutes), [7] .
Lying in a state of perfect unconsciousness (apparently in a profound sleep), from which she could not be roused (after twenty minutes), [15] .
Complete unconsciousness, [19] .
Utter loss of consciousness, [12] .
Vertigo EN
Sensation of vertigo rising from the spine into the occiput (fourth day), [1] .
Vertigo, [16] .
Dizziness, [7] . [20.]
Whirling of the head; sensation as if he would fall forward (second day), [1] .
Sensation as if the ground were waving, on closing the eyes (third day), [1] .
General Head.
Empty feeling in the head (fourth day), [1] .
The head is light, with a peculiar sensation of clearness (first day), [1] .
Heaviness of the head (fourth and fifth days), [1] .
Heaviness in the head and pain in the forehead (sixth day), [1] .
Felt a rush of something to the head, [7] .
Headache, [16] .
Violent headache (after sixteen hours), [16] .
Pressure in various places in the brain (fifth day), [1] . [30.] Pressure in various parts of the brain (sixth day), [1] .
Temples.
Pressing in the temples (fifth day), [1] .
Pressure upon the temples (second day), [1] .
Occiput.
Heaviness of the occiput (fourth day), [1] .
Heaviness in the occiput, with vertigo (fifth day), [1] .
EYE.
Lids.
Inclination to close the eyes (fourth day), [1] .
Eyes closed involuntarily (fifth day), [1] .
The eyes close in spite of one (fourth day), [1] . Lachrymal Apparatus.
Moisture of the eyes (third day), [1] .
Moisture, almost lachrymation of the eyes (third day), [1] .
Conjunctiva. [40.] Conjunctivae injected, [13] .
Conjunctiva quite insensible (after twenty minutes), [15] .
Ball.
The eyes were suddenly turned up, [9] .
Eyes fixed towards upper and inner angle, [5] .
Pupil.
Pupils dilated (third day), [1] .
Pupils dilated (just before death), [20] .
Pupils dilated and insensible, [5] , [11] , [16] .
Pupils widely dilated and insensible, [4] .
Pupils very much dilated, [2] .
Pupils enormously dilated, [12] . [50.]
Pupils very large (third day), [1] .
Pupils contracted (second day), [1] .
Pupils at first contracted (soon), (fifth day), [1] .
Pupils very much contracted (after twenty minutes), [15] .
Pupils greatly contracted, [18] , [19] .
Pupils variable, now dilated, now contracted, [17] .
Pupils during narcosis dilated; afterward, before death, contracted, [10] .
Vision.
Everything seemed more distinct than usual (immediately), [1] .
Dimness before the eyes (sixth day), [1] .
Darkness before the eyes (fourth day), [1] . [60.]
All seemed to grow dark except one bright spot, [23] .
The sight gradually went during inhalation till everything seemed quite dark; it returned gradually , [23] .
Dark points and bright streaks before the eyes (fourth day), [1] .
Small black points float before the eyes (third day), [1] .
Dark spots before the eyes, with bright spots on closing them (fourth day), [1] .
Large black spots before the eyes (second day), [1] . A number of small gray spots and linear bodies appear to float a few inches before the eye; while looking at a distance they follow the motion of the eye; the same appearance before each eye separately (third day), [1] .
Numerous bright points before the eyes, with great inclination to close the eyes, and much yawning (fourth day), [1] .
Bright and dark points; white flames when the eyes are closed, or when looking at a dark background (fifth day), [1] .
Bright and dark spots before the eyes (sixth day after fifteen minutes), [1] . [70.]
Flickering before the eyes (fifth day), [1] . Sparks before the eyes, [16] .
Flashes of light before the eyes, [7] .
Ear. Ears seemed stopped with cotton (fifth day), [1] .
Ringing in the ears (fifth day), [1] , [16] . Roaring in the ears (sixth day), [1] .
Roaring in the ears like boiling water (fifth day), [1] .
Nose EN
Objective.
Nostrils obstructed by swelling of the mucous membrane, [8] .
Bleeding from the left nostril a teaspoonful of dark blood; if afterwards bleeds easily (fifth day), [1] .
Smell.
Sense of smell is weaker than usual (third day), [1] . [80.] Entire loss of smell (lasted two months), [8] .
Face EN
Cadaverous countenance, [4] , [12] .
Expression that of a person partially intoxicated (after half an hour), [3] .
Some flushing of the face, [9] .
Face flushed, [13] .
Face livid, [6] ;
(after two hours), [11] , [19] .
Face became turgid, [9] .
Trismus, [6] .
Teeth EN
Teeth smooth, as after acids (fourth day), [1] .
Tongue.
Tongue pale, [8] . [90.] Tongue covered with frothy saliva (third day), [1] .
Tongue dry and parchment-like, [4] .
General Mouth.
Mouth half open, [4] .
Mucous membrane of mouth and throat flaccid and swollen, [8] .
Foamed at the mouth, [6] .
Complained of the burning sensation the dose produced (immediately), [7] .
Complained of the pungency of the medicine, [3] .
Saliva.
Much saliva (second day), [1] .
Thin saliva (fourth day), [1] .
Taste EN
Soapy taste in the mouth (third day), [1] . [100.] Altered taste of all food and drink, especially coffee (lasted two months), [8] .
Sense of taste abolished, [8] .
Speech.
Could hardly articulate, [2] .
Throat EN
Jugular veins distended, [4] , [11] .
Scraping and dryness in the throat (second day), [1] . Prickling sticking in the throat, especially on swallowing (soon), (second day), [1] .
Fauces.
Fauces very red, with scraping in them (fourth day), [1] .
Violent burning in the fauces and heat in the stomach (immediately after 20 drops), (sixth day), [1] .
Scraping in the fauces (third day), [1] .
Violent scraping and coldness in the fauces, on inspiration (fifth day), (soon after taking), [1] .
Swallowing. [110.] Deglutition interrupted, slow, and difficult, [3] .
Stomach EN
Thirst. Thirst (second day), [18] .
Great thirst at first, [11] .
Eructation and Hiccough.
Eructations tasting ethereal, [1] .
Frequent eructations smelling strongly of chloroform, and causing prickling in the nose (fourth day), [1] .
Constant hiccough, [17] .
Nausea and Vomiting.
Nausea (sixth day), [1] ;
(second day), [18] .
Nausea, with much saliva (fifth day), [1] .
Urging to vomit (fifth day), [1] . Vomiting, [9] . [120.] Vomiting (soon after), [12] , [14] .
Violent vomiting, [17] .
Stomach EN
Pain in the epigastrium (during convalescence), [19] .
Severe pain about region of stomach and spleen, [5] .
Burning in stomach, [3] .
Burning in the stomach alternating with chilliness (fifth day), [1] . Pressure in the stomach (third day), [1] .
Pressure in the stomach, increased by external pressure (third day), [1] . Pressure in the stomach, with nausea (fifth day), [1] .
Dull pressure in the stomach (third day), [1] .
Abdomen EN
Objective. [130.] Abdomen tense (before death), [10] .
Rumbling, with passage of flatus (fifth day), [1] .
Rumbling in the abdomen (fourth day), [1] .
Rumbling in the abdomen, with passage of flatus (third day), [1] .
Much rumbling in the abdomen, with warmth (third day), [1] .
Passage of much flatus (third day), [1] .
Abdomen painful (second day), [18] . Cuttings deep from the stomach to the navel (second day), [1] .
Rectum And Anus. Although the rectum and intestines were as torpid as the genital organs, yet the sphincter ani preserved its contractility, [8] .
Stool EN
Diarrhoea.
Bloody diarrhoea (during convalescence), [19] . [140.] On two occasions, I have noticed involuntary discharge of faeces, [23] .
Much blood in the stools (second day), [18] .
Constipation.
Constipation sometimes lasted eight days, but without giving rise to uneasiness, [8] . The torpidity of the large intestine was such that he was obliged to resort continually to cathartics, [8] .
Urinary Organs EN
Urethra.
Emission of urine painless, but accompanied with a curious sensation along the urethra, [8] .
Stitches in the urethra (fifth day), [1] .
Voluptuous tickling at the orifice of the urethra, with erections and desire to urinate (fourth day), [1] .
Much desire to urinate (fourth day), [1] .
Micturition. Urine increased in quantity (third and fourth day), [1] .
Bladder distended, and bedclothes stained by urine that had escaped, [4] . [150.]
When the bladder was distended, the urine was only expelled after much effort, [8] . Urine suppressed, [10] .
Urine EN
Urine dark yellow (fourth day), [1] . Specific gravity of urine rather lower than normal; it contained a large proportion of triple phosphates, and traces of uric acid crystals, [8] .
Sexual Organs EN
Genitals as if much shrivelled (third day), [1] .
On one occasion erection of the penis occurred, [23] .
No erections for two months, [8] .
Sexual desire, with a peculiar feeling in the testicles, which made him believe that the spermatic secretion still continued, and that the impotence was owing to paralysis of the perineal muscles, [8] .
Sexual appetite wanting, and the generative functions in a languid state, for several weeks, [8] .
Respiratory Organs.
Tracheal râle, [12] .
He spoke in an altered drawling voice, [23] . [160.] Loss of power of speech; could not utter any sound whatever; remained in that state for five weeks, after which she began to speak in a low tone, [22] .
Respiration stertorous, [12] ;
(after ten minutes), [14] , [16] .
Breath smelt of chloroform, [5] .
Short, quick, irregular, and superficial breathing, [3] .
Breathing slow and stertorous, [5] . Respiration became very slow (2), and stertorous, [19] .
Respiration very slow and deep (sixth day), [1] .
Respiration became very slow, full, and deep, [21] .
Respiration very slow and difficult, [11] .
Respiration very slow, with plainly perceptible beating of the heart internally (fourth day), [1] . [170.] Respiration 15 (usually 22), (soon), (sixth day), [1] . Respiration fell to two in a minute, [18] .
Deep, slow respiration (after one hour); respiration very slow, fifteen to the minute, superficial, with at times deep inspiration (after one hour and a quarter), (fifth day), [1] . Frequent deep breathing (fifth day), [1] .
Respiration during narcosis feeble and slow, afterward before death it became rapid, deep, and rattling, [10] .
Irregular respirations, [6] .
Respirations sometimes irregular and short, at others deeper and separated by longer intervals, [4] .
Some oppression of breathing, [5] .
Respiration appears embarrassed, [5] .
Respiration arrested every now and then, [12] . [180.]
Eight or ten inspirations were distinctly remarked after the complete and entire cessation of the cardiac movements, [13] .
Chest EN
Slow, but regular, heaving of the chest, with some subsultus of the muscles, [4] .
Moist crepitation over lungs, [5] .
Tension in the chest and bruised feelings in the joints (fourth day), [1] .
Oppression of the chest, with slow respiration for a long time (fifth day), [1] .
Sternum.
Pain in the right margin of the sternum, deeply seated (fourth day), [1] .
Pressure behind the sternum (fifth day), [1] .
Heart And Pulse. Praecordium.
Pressure on the heart (sixth day), [1] . Stitches in the region of the heart and upper half of the left lung (sixth day), [1] .
Internal pulsation of the heart, like a trembling, rather more while sitting, with oppression of the chest, nearly the whole day (fifth day), [1] .
Heart's Action. [190.] Action of heart occasionally tumultuous, [12] .
Beating of the heart powerful, rapid, felt through the whole chest into the arms, and moving the book held in the right hand (first day), [1] .
Beating of the heart felt in the chest without being noticed in the hand (fourth day), [1] .
Heart beat so feebly that it required sustained attention to perceive its weak and rare contractions, [4] .
Heart-sounds feeble, [5] .
Pulse EN
Pulse frequent and undulating, [6] . Pulse rapid and weak, [17] .
Pulse more rapid than usual (immediately), [1] .
Pulse at first increased, afterwards small and indistinct, [11] .
Pulse 78, soft and tolerably full (after twenty minutes), [15] . [200.] Pulse 100 and feeble; afterwards insensible, [12] .
Pulse 100 to 120, soft (second day), [18] .
Pulse slower than normal (at first), [21] .
Pulse became slower, and suddenly stopped, [21] .
Pulse 64, usually 75 (third day), [1] .
Pulse about 60 (after ten minutes), [14] .
Pulse 60 (after half an hour), (fourth day), [1] .
Pulse 56 (after one hour), (fourth day), [1] .
Pulse 50, very weak, [16] .
Pulse weak and slow, afterwards, just before death, it became full and strong; then rapid (160), and weak, [10] . [210.]
Pulse 95 (after ten minutes); 65 (after half an hour); 70 (after three-quarters of an hour); 54 (after one hour and a quarter); 66 (after two hours and a half), [1] .
Pulse 63, irregular; before the proving 70 to 75 (fifteen minutes after 12 drops), (fourth day), [1] . Pulse soon after taking small, irregular, scarcely perceptible, 80; after a few minutes 85, regular; after half an hour 70, for several beats in succession; then again some very slow beats; 62 (after three-quarters of an hour), firm; 64 (after one hour); 58 (after one hour and a half); 70 (after two hours and a half), (fifth day), [1] .
Pulse very irregular, at one time very slow, then soon again rapid beats in quick succession (second day), [1] .
Pulse small (third day, three-quarters of an hour after 8 drops), [1] .
Pulse small and fast failing, [5] . Pulse became very weak, [19] .
Almost imperceptible pulse, [3] .
Almost pulseless, [2] .
Pulse suddenly ceased, face became pale, [20] . [220.] Pulse, from beating at the rate of 100, stopped as if it had been struck with lightning, [9] .
Neck And Back. Veins of neck swollen, [13] .
Dull pains in the region of the kidneys (second day), [18] .
Extremities In General.
Objective.
During commencing anaesthesia, twitching of the muscles of the extremities, especially of the arms, [21] .
Cracking in the joints and loss of power in them, on moving (fifth day), [1] .
Excessive weakness in the limbs (fourth day), [1] .
Complete resolution of the limbs, [12] .
Subjective.
Compressed sensation in the right ankle and left elbow (second day), [1] .
Bruised pain in the shoulder and ankle-joints (third day), [1] .
Feels very much bruised in all the limbs (sixth day), [1] .
Superior Extremities. [230.]
Bruised sensation in the arms (fifth day), [1] .
Forearm.
Pressing pain in the muscles of the right forearm and in the flesh above the hollow of the right knee (second day), [1] .
Hand.
Peculiar unsteadiness of the hands, with sensation of prostration (second day), [1] .
Fingers.
Finger-nails blue (fourth day), [1] .
Fingers convulsively pressed against the palms of the hands, leaving impressions of the nails, [4] .
Inferior Extremities.
Staggered in walking (after half an hour), [3] .
Constant painful weakness in the whole left leg, especially the lower leg and calf (first day), [1] .
Great weakness in the feet (fifth day), [1] .
Generalities EN
Objective.
Great nervous excitement, [16] . The muscles stiffened, [13] . [240.] Muscles become relaxed, [9] .
Frequent stretching and yawning (fifth day), [1] . Very feeble, [7] . Every exertion of the muscles fatigues very soon (third day), [1] . Restless and tossing about before death, [10] . Subjective. Anaesthesia, with muscular resolution, [13] . Absolute general anaesthesia, [12] .
Complete loss of sensibility and recognition, but not of self-consciousness. (Hirschell), [11] . Sense of touch perverted, [8] .
When under its influence, felt extremely comfortable; could have remained as she was forever, [23] .
She felt as if floating on wings, [23] . [250.] Excessive weariness in all the joints, especially the ankles (third day), [1] .
Sensation as if the seat were tottering (fifth day), [1] . While sitting, a sensation as if the chair and table were moving in different directions (third day), [1] . Felt queer twitchings in her body, which lasted over twenty-four hours, [7] .
Felt as if hammers were beating all over her, [23] .
Skin EN
Skin very blue, with coldness of the eyes (fourth day), [1] . Tingling of the limbs, [7] .
Crawling in the left fingers (first day), [1] .
Sleep And Dreams. Yawning (fourth day), [1] .
Much yawning and closing of the eyes, even while walking (sixth day), [1] . [260.]
Excessive yawning, as though he would dislocate the jaw (third day), [1] . Great sleepiness and much yawning (fourth day), [1] .
A very agreeable sensation of sleepiness, with a very quiet mood (fourth day), [1] .
Very sleepy, with chilliness and cold extremities (sixth day), [1] .
Much sleep (fourth day), [1] .
Apparently deep unconscious sleep, from which she could not be awakened, [18] .
Comatose sleep, [16] .
After vomiting had been induced, sank quickly and suddenly into a profound and alarming coma, characterized by excessive pallor of the features, sunken eyes, contracted pupils, insensibility of the cornea, perfect and universal muscular relaxation, complete anaesthesia, coldness of the extremities, [3] .
Fever EN
Chilliness.
Skin cold, pale, [16] .
Cold skin, especially on the extremities, with chilliness in the back, during the whole proving, [1] . [270.] Surface of body cold and clammy, [5] .
Constant chilliness, with cold extremities (third day), [1] .
Internal chilliness (fourth day), [1] . Much internal chilliness, with cold skin (fifth day), [1] .
Very cold, [2] .
Temperature during narcosis diminished, but before death increased, [10] .
Chilliness deep in the back, extending to the temples (sixth day), [1] .
Great coldness in the innermost portion of the spine, with coldness and paleness (after one hour and a half), (fourth day), [1] .
Extremities cool, [11] .
Heat.
Feverish excitement (after sixteen hours), [16] . [280.] Heat in the head (sixth day), [1] .
Head hot, [11] .
Heat in the occiput (fifth day), [1] .
Warmth in the stomach (fourth day), [1] .
Sensation of warmth in the bronchi that increases to a biting-burning, with a very troublesome constriction of the larynx, and with difficult interrupted sighing respiration, even amounting to a suffocative anxiety, [16] .
Sweat.
Sweat copious before death, [10] .
Aggravation EN
( On closing eyes ), Sensation in head.
( On inspiration ), Scraping, etc., in fauces.
( External pressure ), Pressure in stomach.
( Sitting ), Pulsation of heart.
Amelioration EN
( Brandy ), The symptoms.