Solaninum
T. F. Allen - Encyclopaedia of Pure Materia Medica · Timothy Field Allen · 3,207 chars
General
An alkaloid, C 43 H 69 NO 16 , obtained from Solanums, especially from S. nigrum and S. dulcamara.
Preparation , Triturations.
Authorities. Reil's Journ. f. Pharmacodynam., 1857. 1 , Dr. Clarus, took 1/2 grain of the acetate first day, 1 grain second day, 6 1/2 grains third day; 2 , Schroff, Lehrbuch f. Pharm., 4th ed., p. 623, proving of Solanin from S. dulcamara on four persons; 3 , Froumüller, Klin. Studien, etc., gave to several persons doses of 1 to 4 grains of S. from S. tuberosum and nigrum, no symptoms; afterwards took 6 grains; 3 a , same, persons took 15 grains.
Mind
Stupefaction without previous excitement, [2] .
Head
Vertigo, [2] , [3a] .
Head hot, heavy, dull painful, [2] .
Heaviness of the head, [1] .
Pain in the occiput, [1] .
Eye.
The pupils were not much affected, perhaps somewhat contracted, [1] .
Mouth
Salivation, [2] .
The pure alkaloid has a cooling, acid, and salt taste, and when chewed, it causes a glutinous sensation in the pharynx and throat, with scraping, which extends down to the stomach, where it becomes a peculiar sticking pain, [2] .
Bitter taste, [3] .
Throat
[10.]
Scraping in the throat, [1] , [2] , [3a] .
Stomach
Constant eructations, [2] . Nausea and diarrhoea, [3a] .
Nausea, and violent ineffectual efforts to vomit, [2] .
Nausea and vomiting, [3] .
About 5 P.M., vomiting three times without previous nausea, without pain and without any intestinal symptoms, [1] .
Abdomen
Rumbling in the abdomen, [2] .
Urinary Organs
(The next morning, examination of the urine showed albumen!), [1] .
Respiratory Organs.
Hoarseness, [2] . Respiration slightly slower than natural, temperature not affected, [3a] . [20.]
Very superficial slow respiration, 15 or 16 to 14 to the minute, [1] .
Difficult respiration, with oppression of the chest, [2] .
Oppressed respiration, [1] .
Pulse
Pulse increased in rapidity, weak (72 to 88), [1] .
Increased frequency of the pulse, sometimes as much as 25 beats, lasting four hours (the next morning, somewhat slower than natural), [2] .
The pulse ran up to 95 and 100, was remarkably soft, small, and weak, [1] .
Pulse rose from 76 to 92 in fifteen minutes; in twenty minutes more it returned to the normal, [3a] . It caused after ten hours slight slowness of the pulse and respiration, but no change in the temperature, [3] .
Pulse small, weak, thready, [2] .
Inferior Extremities. Slight tonic spasms of the lower extremities, [2] . [30.]
The next morning the prover felt quite well, with the exception of some weakness in the lower extremities, [1] .
Generalities
Weakness, [1] . Sensation of great weakness, [2] .
Sensitiveness to light, noise, and to touch, [1] .
Skin
Skin dry, [2] .
Hyperaesthesia of the skin; creeping along the spine when touching the skin; more easily tickled than natural, [2] .
Itching of the skin, [2] .
Sleep
Frequent yawning, [2] . Great sleepiness, with inability to sleep, [2] .
Sleepiness, [2] . [40.]
Sleep very restless, frequently disturbed by frightful dreams, [2] .
Sleep frequently interrupted during the night, but without dreams, [1] .
Fever
Extremities cold, [2] . Profuse perspiration without weakness, [1] .