Colchicinum

T. F. Allen - Encyclopaedia of Pure Materia Medica · Timothy Field Allen · 2,638 chars

General

Alkaloid from Colchicum autumnale; Formula, C 17 H 19 NO 5 .

Preparation , Triturations.

Authorities. 1 , Schroff's provings, Oest. Zeit. f. Pract. Heilk., 1856, 22-24, Heinrich took .01 of a gramme, and after a week took .02 gramme; 2 , the only case of poisoning known, Ber. Rudolph-stift, 227, 1867, a woman, aged twenty, took a solution of 45 milligrammes (Husemann's Pflanzenstoffe, 498).

Eye. Pupils widely dilated, [2] .

Face

Tearing pains in the face, [2] .

Mouth

Increased secretion of saliva, [1] .

Stomach

Eructation.

Eructations, nausea, and great desire to vomit, [1] . Nausea and Vomiting.

Slight nausea, and an uncomfortable sensation, which distracted the attention of the prover from the lecture to which he was listening, [1] .

On rising from bed, at night, nausea suddenly increased, and was followed by vomiting of undigested food, and afterwards of a bitter greenish fluid; the vomiting was repeated early in the morning, [1] .

Vomiting of greenish substances, frequently repeated, [2] .

Vomiting of blood for nine or ten days, [2] .

Stomach

Pains in epigastric region (after four hours), [2] . [10.]

Excessive sensitiveness of epigastric region, [2] .

Abdomen

Distension and sensitiveness in the abdomen, [1] . Frequent rumbling in the bowels, [1] .

Rectum And Anus. Urging to stool, causing him to leave his bed, followed by copious pasty evacuation, with excessive tenesmus; this was repeated three times within a short period, [1] .

Stool

Two stools on the second day, one on the third day, three on the fourth day, all accompanied by tenesmus, and consisting of a thin fluid with numerous flakes, looking like the cooked white or an egg, in pieces from two to four lines long, [1] . Stools thin, yellowish-green, and slimy, accompanied by pain (second day), [1] .

Liquid stools, [2] .

Urinary Organs

Urine turbid, depositing a copious white sediment, [1] .

Heart And Pulse.

Pulse 96, [2] .

Pulse during the first two hours gradually sank about eleven beats, [1] .

Superior Extremities. [20.]

Convulsive jerkings of right hand, [2] .

General Symptoms. Very great exhaustion on the second day after taking Colchicin, increased to a feverish excitement, lasting for two days, so that he was obliged to keep his bed on the second day, [1] .

Sleep And Dreams. Slight somnolency and collapse, [2] .

Awakened from sleep soon after midnight by uneasy dreams, [1] .

Fever

The fever appeared as a chill about noon on the first day, followed by violent heat, lasting several hours, with increased thirst, very rapid pulse, confusion of the head, uneasiness, and sleeplessness, [1] .