Authority. C. Voigt, M.D., Med. Examiner (Bost. Med. and Surg. Journ., vol. xxxiv, p. 308), effects of about 3 grains. In about an hour attacked by a sense of tightness in the praecordia and around the chest; nausea; thirst; a hard, small, frequent pulse; and a collapsed state of the circulation. These disturbances were followed by a fulness and tension in the head; heaviness in the limbs; and an unsteady tottering gait.