[A plant used by the natives of Peru, for the purpose of etimulation, and to eoable them to p«rfomi ardnoas hibor. Tliuse Bjmptoms are eollaied mainly from Bering's patliogenesis.— Hale.] Pharmacology.— This is a shrub growing wild, in Sontli Amrrica, and largely cultivated in Boljria, for the sake of il^ leaves, wbicli nre much dbyGooglc 214 oocA. used in tliat country for chewing. The plant which is propagated from tlie seed in nurseries, begins to yield in eighteen months, and continues productive for half a century. The leaves, on being picked, are dried in tiie 3ua, and then pacltcd in bags. They are known in South America by the name of Coca. They were in general use among tiie natives of Peru, at the time of the conquest, and have continued to be much employed to the present time. The leaves rescmblo in size and shape those of tea, being oval-oblong, pointed, two inches or more in length, hy somewhat over .an inch in their greatest breadth, and furnished -with short delicate footstalks; but they are not, like tlie tea leaves, dentate, and are distinguished from most other leaves by a. slightly cun'ed line on each side of the mid-rib, running fl'om the base to the apex. When well dried, they resemble, in odor, lea, and a peculiar taste, wJiich, in decoction, becomes bitter and astringent. It has been found so impossible to import the leaves to this country without injury to their medicinal properties, that the tincture ought to be prepared from them as soon as gathered- OsTiciNAL PaKPABATiowe. — Tinctiwe with strong alcohol, from fre^ leaves, dilutions. ASALOatiEB. — Coffea, Tkea, ScufeRwria, Ignatia, PauUifiia, Cann^ii indiaa, Gypripedivm, Pficspfume aeid, ete. Mental Sphere. * Slow ill fir.ding the words to express himself at times. * Erain feels so muddled that he cannot read under standingly. "Mind much clearer; spirits much better. A peculiar sensation of isolation -from the outer world. On any one speaking to him, it seems as if the person were at a great distance. Their excited imaginations conjure up the most wonderful visions; at one time consisting of indeBcribahly heautiful and delightful forms; at another, however, of the most horrid figures. Inclination to work, with sleeplessness all night; disinclination. An irresistible inclination to feats of strength. Shy; they ilee the society of tlieir fellow-men; seek conceal- ment in gloomy woods or lonely dwellings. Instinctive desire to make no motions at all. 'Always relieves him from unusual fatigue; producing per- fect calmness of mind and body, and is never followed by any depression, A kind of numbness, with a feeling of secnrity, with retention of clear self- consciousness, and the. instinctive desire to dbyGooglc mak. 215 m^e so motion, not even to move a single finger, for an entire day. During the evening, after the first dose at six o'clock, his hearing became painfully acute; he felt something like expectation; brain excited; and a i-atber painful pi-essuro on the sides of the head. " Mental depression. Great anxiety, palpitation, humming in the ears the whole day, and sparks before the eyes. "Peevish temper; hypochondria. I^^ausea and vertiginous feeling, ineapaeiting Ibr carrying oa literary labors. " Loss of e Giddiness and dizziness; involuntarily stopping quickly when walking; the head inclined forward, with giddiness and fear of walking. Giddiness, tliotigh slight, on going out in the open air early in the morning; objects appearing to turn before the eyes, for an hour's time. Great dullness in the head, like the effects of a debauch. Fullness of forehead; dull feeling over the whole brow; slight shooting pains in right temple; sensation of tension over forehead, as if an india rubber band were stretched over it. Tiolent headache immediately over the eyes, with low ringing in tlie ears, jDull frontal headache, which vanished with the setting of the sun, followed by a state of mental exhilaration. A pressing headache on the right side of the occiput as well as of the right side of the forehead, with giddiness and chill after dinner, disappearing toward evening. Headache in the afternoon, with chilliness. !Eather violent headache, with sensation of dryness in the