Apium virus ; poison of the honey bee. General Analysis.- Apis acts specifically upon the cellular tissues, giving as its most characteristic effect an acute oedema both of the skin and the mucous membranes. On the skin it also produces an eruption resembling urticaria, and in the mucous membranes it has the power of irritation, extending to a mild, inflammatory condition. Apis also affects the serous membranes, producing conditions similar to those which are the products of serous inflammations-hydrocephalus, hydrothorax, ascites, etc., but it does not appear to have in itself the power of producing serous inflammation. Apis acts prominently upon the ovaries and the uterus, producing irritation, congestion, mild inflammation, and dropsy of these organs. Characteristic symptoms.