Rapid change of symptoms-pains change in regard to place and character-thirst alternates with thirstlessness, hunger, and loss of appetite, etc. Acts forcibly on the venous system, producing pelvic engorgements and haemorrhoids. Hepatic, and rheumatic affections, particularly with urinary, haemorrhoidal and menstrual complaints. Old gouty constitutions. Pain in region of kidneys is most marked; hence its use in renal and vesical troubles, gall-stones, and vesical catarrh. It causes inflammation of kidneys with haematuria. Pains may be felt all over body, emanating from small of back. It has also marked action on the liver, promoting the flow of bile. Often called for in arthritic affections with urinary disturbances. Wandering, radiating pains. Acts well in fleshy persons, good livers, but with little endurance. Spinal irritation. All Berberis pains radiate, are not worse by pressure, but worse in various attitudes, especially standing and active exercise.