One of the most important tissue remedies, and while it has many symptoms in common with Calcarea carb, there are some differences and characteristic features of its own. It is especially indicated in tardy dentition and troubles incident to that period, bone disease non-union of fractured bones, and the anaemias after acute diseases and chronic wasting diseases. Anaemic children who are peevish, flabby, have cold extremities and feeble digestion. It has a special affinity where bones form sutures or symphyses, and all its symptoms are worse from any change of weather. Numbness and crawling are characteristic sensations, and tendency to perspiration and glandular enlargement are symptoms it shares with the carbonate. Scrofulosis, chlorosis and phthisis.