upon the ganglionic nervous system, more especially upon that portion which presides over the functions of vegetation, producing a condition of general depression and exhaustion, diminishing the vital turgor, and modifying the digestive functions. The quantity and quality of the blood are altered. It becomes thin and watery, the circulation lacks energy, and, as a consequence, we have general debility and erethism, while various functional disturbances are manifest, such as haemorrhage, profuse sweat and urine, watery diarrhoea, etc. In the vegetative sphere Cinchona shows a special affinity for the liver and spleen, and here may be said to exist its most important relations. In the liver it produces hyperaemia and congestion, prostrating all functional performance, and giving rise to a long train of biliary symptoms, of which jaundice is one of great importance. In the spleen, it also produces hyperaemia, which tends to congestion, and finally to enlargement of the organ. Through the ganglionic nervous system, and in connection with the disturbances of the system above set forth, Cinchona has a fever-producing power in an eminent degree, the latter almost invariably partaking of that character which in disease would indicate a malarial origin, periodicity being one of its most essential features. The chief characteristic of Cinchona is an excessive sensitiveness of the nervous system, all symptoms being aggravated by the slightest contact, by motion, and by physical or mental effort. Also prostration, with neither thirst nor hunger. Characteristic symptoms.