Nitro-glycerine was discovered by Sobrero, In 1847, but none could be obtained for physiological experiment until Morris Davis, a Philadelphia chemist, in the same year, after long and laborious trial, under direction of Hering, succeeded to produce the substance in sufficient quantity for proving. It was extensively proven here and abroad (See Allen's Encyclopaedia, vol. 4, p. 425), and the symptoms have received abundant clinical verification. Clinical Authorities. — Mania, Field, B. J. H., vol. 16, p. 519; Loss of location, Cochran, Hah. Mo.; vol. 5, p. 23 ; Affection of brain, Lippe, Kaue's E.ec., 1874, p. 63 ; Hypercemia of brain, Mossa, Raue's Eec, 1874, p. 62 ; Congestion to head, Okie, B. J. H., vol. 11, p. 287; Congestion to head, (2 cases), Okie, B. J. H., vol. 11, p. 288; Cerebral congestion, Battman, B. J. H., vol., 23, p. 436; Congestion to brain, Coxe, N. A. J. H., vol. 6, p. 76 ; Symptoms of cerebrospinal meningitis. Smith, ]Sr. E. M. G., vol. 9, p. 492; Cerebrospinal meningitis. Von Tagen, Raue's Rec, 1874, p. 66; Vertigo, Gardiner, N. E. M. G., vol. 9, p. 394 ; Sunstroke, For. N. E. M. G., vol. 9, p. 394; Von Tagen, Organon, vol. 3, p. 106; Effects of expos- ure to sun. Small, N. E. M. G. vol. 9, p. 394; Campos, B. J. H., vol. 11, p. 287. Sun-headaches, McCIatchey, Hah. Mo., vol. 6, p. 36 ; Headache, Neuralgia, Field, B. J. H., vol. 16, p. 336 ; Headache (2 cases), Vinal, B. J. H., vol. 7, p. 421 ; Raue, B. J. H., vol. 11, p. 288; Hering, B. J. H., vol. 11, p. 287 ; Hirscliel, N. E. M. G., vol. 9, p. 433; Battman, N. E. M, G., vol. 9, p. 487 ; Geist, N. E. M. G., vol. 9, p. 441 ; Berridge, N. E. M. G., vol. 9, p. 439 ; A. J. H. M. M., vol. 4, p. 47 ; Thayer, N. E. M. G., vol. 9, p. 536; Willard, Raue's Rec, 1874, p. 258; A. H. O., vol. 10, p. 477; Boardman, A. H. O., vol. 13, p. 216; Fehrman. Med. Inv., vol. 8, p. 190; (4 cases), Coxe, N. A. J. H., vol. 6, p. 76 ; Headache after hemorrhage, Nicholls, N. A. J. H., vol. 5, p. 439 ; Headache in a chlorotic patient, Menz, N. E. M. G., vol. 9, p. 489; Hemicrania, Field, B. J. H., vol. 16, p. 520; (6 cases), Lichtenfels, Eichorn, N. E. M. G., vol. 9, p. 482; Supra-orbital neuralgia. Field, B. J. H., vol. 16, p. 520; Paralysis of auditory nerve, Coxe, B. J. H., vol. 11, p. 291 ; Facial neu- ralgia (3 cases), Brady, Nankivell, N. E. M. G., vol. 9, p. 531 ; Toothache (3 cases), Field, Nankivell, N. E. M. G., vol. 9, p. 532; B. J. H., vol. 16, p. 335; (2 cases), Gaillard, Raue's Rec, 1870, p. 138; Aphasia, Burnett, Raue's Rec, 1874, p. 61; Suppression of menses, Hah. Hospital, B. J. H., vol. 11, p. 291 ; Climacteric com- plaints, Raron, Raue's Rec, 1874, p. 237 ; Congestion of blood to head during preg- nancy and during menses, Hering, B. J. PI., vol. 11, p. 288; Convulsions after labor, Battman, B. J. H., vol. 23, p. 435 ; Palpitation of heart (2 cases), Dunham, B. J. H., vol. 11, p. 287; Hah. Hospital, B. J. H., vol. 11, p. 290; Neurosis cordis, Kafka, Raue's Rec, 1874, p. 165 ; Acute rheumatism in I. knee, Benson, MSS. ; Nervous affec- tions, Nankivell, Am. Hom. Rev., vol. 3, p. 465 ; Neuralgic affections, Brady, B. J. H., vol. 18, p. 137 ; Neuralgia, Field, B. J. H., vol. 16, p. 519 ; Convulsions, Wes- selhceft, Raue's Rec, 1871, p. 185 ; Parcdytic symptoms, Hawkins, Raue's Rec, 1874, p. 271 ; Effects of violent jarring, Wesselhceft, N, E. M. G., vol. 9, p. 493. GLONOINUM. 408 ^ Mind. ■ Loses senses, sinks down unconscious; congestion alternately to head and heart. ■ Recognized no one; repulsed her husband and children; raved, screamed, and wished to rush from house; jumped out of bed, but fell because her knees gave way. I She could not remember which side of the street her house was on. llAVell-known streets seem strange; way home too long. ■ Loses his w^ay in the known streets. The chin feels too long. • Loss of location; commenced about ten years ago; loses himself, even when walking in streets that he has trav- eled in for years; all right in regard to everything else. Long forgotten old offences come back to him. ■ Frantic ; attempted to jumjD from the window. ^Headache. lAfter an attack of epilepsy patient awoke in a state of violent mania, struggling with great violence ; eyeballs projecting, mouth half open, looked as if he were con- templating some afflicting sight, while he rapidly reit- erated an unmeaning monosyllable, cloe-doe-doe, in a painfully plaintive voice. I I Unusually bright and loquacious, with great flow of ideas. I I Great mental agitation ; attempts to run away ; at- tempted to spring from window. I I During intermissions of pain, she shudders and weej)s bitterly. I I Disinclined to speak ; would scarcely answer. Fear; throat feels swollen ; chest as if screwed together; apprehensive of approaching death ; fears she has been poisoned. iBad effects of mental excitement, fright, fear, mechanical contusions and their later consequences. ^ Sensorium. ■ l Heaviness in head, principally in forehead. I Fulness in head, as if all blood had mounted to head; very disagreeable sensation, but without pain. Fulness in head, as if brain was expanding itself, were moving in waves. ■Sensation in head as if he were hanging with head down- wards, and as if there was a great rush of blood to head in consequence. ■ Determination of blood to head sometimes preceding apo- plexy, also for that which often occurs in softening and tumors of brain. ■ Could not allow his head to be on a level with his body, but must have it elevated, it felt full, could not see ob- jects distinctly ; dizzy. I I Giddiness when the head is moved. 409 GLONOINUM. I Confusion and vertigo; after stooping. I I Throbbing, pulsation and confusion of all senses ; sensa- tion of balancing, requiring a constant effort to keep head erect, which inclined to droop as on going to sleep. I I Undulating sensation in head. I Head feels larger. ■ Vertigo; confusion, fain tness, black spots before eyes; < stooping or moving head ; < in open air ; with head- ache ; with nausea ; in sunstroke ; after a violent fall on head ; when rising in morning. ■ Congestive vertigo ; forerunner of apoplexy; intoxication and heaviness of head, with bending head forward ; reeling, trembling, falling ; headache ; heat in head ; redness of face ; pJiotophobia ; injection of conjunctivee ; flickering before eyes ; buzzing in ears ; pulsation of carotids ; < sitting up. I Nausea, then unconsciousness, with convulsive action of facial muscles; face pale, breathing stertorous, feeble