Gratiola is one of the most important members of the great Scrophularian group—Digit., Euphras., Tabac., Scroph.—and should be carefully studied with these. A large proportion of the effects of Gratiola are expended on the gastro-intestinal tract. It is an inodorous plant, of bitter taste, and very poisonous, causing violent colic, diarrhoea, bloody stools, enteritis, jaundice, trembling of extremities, convulsions, cramps, excitement and disordered condition of the sexual powers, and death. Symptoms of a fully developed, rapid attack of Asiatic cholera are produced. On the other hand, the mind is strongly affected. Peevishness, ill-humour; irresolute; hysterical; cerebral affections without fever. It is useful in mental troubles from overweening pride. Teste considers Gratiola the Chamom. of chronic diseases. There is < during and after eating: vertigo during and after a meal. Hunger after a meal with feeling of emptiness. The diarrhoea is yellowish, gushing, watery, as though rushing from a hydrant. There is also vomiting of yellowish fluid. Summer diarrhoea from excessive drinking of water whether cold or hot. Soreness, burning or irritation of anus follows the stools. Two excellent cures with Gratiola have been recorded by C. W. Sonnenschmidt (H. R., xi. 547). (1) Mrs. C., 53, attacked in June with diarrhoea; yellow, watery, frothy stools gushing out with force. Severe cutting pains in abdomen; rumbling of flatulence. Occasional nausea and vomiting. Coloc. and Ipec. failed to relieve; then on close inquiry it was elicited that "a cold feeling in the abdomen" had been a feature throughout. Grat. off. 3, cured promptly. (2) A three-weeks' old infant was attacked with diarrhoea and colic. There were two or three passages in quick succession, and then an interval of an hour or two. Passages green or yellow, watery, frothy, expelled suddenly; nausea, vomiting, severe pain before stools, relieved after, for a short time. Cham., Coloc., Verat. failed and Grat. rapidly cured. It also removed in this case "redness around anus, and on one side an abrasion of half an inch in extent, which caused some oozing of blood." E. E. Case (Med. Adv., xxix. 343) cured a woman, aet. 50, of haemorrhoids with the following symptoms: (1) Constipation, difficult stools. (2) External piles from any exertion and after stool. (3) Biting, stinging tension in tumours. (4) During stool, a sensation as if the rectal membrane was torn. (5) After stool, all the nerves of the pelvis seem in a high state of tension; the flesh on the perineum feels as if torn from the bone. [Compare "Wrenching pain in coccyx."] Sleepless before midnight; peevish; melancholy. Grat. 200 cured. Cooper has used it with great success in a case of gouty acidity with great constipation; and in the constipation of cancer. He regards it as "the vegetable antacid." It is said to have formed the basis for a once famous nostrum for gout, "Eau Médicinale." Indications are: Constant sinking but cannot eat; bitter taste. The affection of the solar plexus is very marked; cramps beginning at pit of stomach, and pains radiating therefrom; anxiety; gnawing; empty feeling; rolling about in epigastric region. Urine is diminished, reddish, turbid. Buvier, says Teste, saw four cases of nymphomania in females to whom herb-doctors had given injections of a decoction of freshly gathered Gratiola. Burnett considers it specific in female masturbation and nymphomania. A number of pains are experienced in the coccyx. Chilly; shuddering on entering a warm room. Heat ascending to face, with redness and increased external warmth. Constant vaporous exhalation from body. Sensations: as if brain contracted; as if head grew smaller; as if brain would fall forward; as if sand in eyes; as if throat contracted; as if a stone rolling from side to side in stomach. The left side is more affected than the right. The head and eye symptoms are of the first importance. Rush of blood to head with vanishing of sight I consider a keynote. With Grat. 30. I cured this symptom in a patient: "Sometimes everything seems to assume a yellowish tint, and occasionally, when I have been taking notes, a rush of blood to my head seems to shut the book from my sight and for the moment I have been unable to follow the speaker by writing although I could by thought." Motion <; rest >. > In open air; < in warm room (some headaches, and vertigo have the opposite modality). Coffee = neuralgia.