This is the first alkaloid of Hydrastis that was isolated. Hale commends it as excellent for local applications, in the strength of about ten grains to eight ounces, stronger or weaker according to sensitiveness, in cases of aphthous sore mouth, ulcers (malignant or simple), ozaena, and generally in cases for which Hydrastis is being given internally. The alkaloids of Hydrastis deserve separate proving. Old school practitioners have used this salt largely as an internal remedy in uterine haemorrhage.