1 . Patients intellectually keen but physically weak ; emaciation upper part of body ; sedentary habit ; mentally absorbed ; complexion often sallow ; prematurely old in appearance. Children precocious, weakly. 2 . Mental powers failing ; fatigue and forgetfulness ; uses wrong words, etc. ; hypochondriasis with irritability ; emotionally sensitive ; lachrymose ; apprehensive of the future ; lacks self-confidence yet "gets through" ; dislikes company yet dreads solitude ; in women dread of men. 3 . Chronic gastro-intestinal disorders ; general sourness of alimentary tract ; appetite good but a few mouthfuls-satiate ; flatulence excessive , much borborygmus, > dejections ; craves sweets, delicacies ; dislikes oysters and often meat ; < coffee, wine, smoking, onions ; constipation predominates. 4 . Uric acid diathesis ; red sand in urine , child cries before micturition ; or increased quantity of pale urine 5 . Dryness of skin (especially, palms) and mucous membranes ; stoppage of nose with discharge of crusts or elastic plugs. 6 . Fan-like motion of the alae nasi, of a twitching nature and independent of respiration (in respiratory troubles – Antimonium tartaricum ). 7 . One foot hot (usually the right) the other cold. 8 . Irritability after uninterrupted nap. 9 . Complaints right-sided or travel from right to left. 10 . Modalities ; < both extremes of temperature but especially heat ; heat of exertion ; < 4-8 p.m. , sometimes continuing later ( Helleborus niger ) ; sleep ; constriction ; in open air especially with uncovering and gentle motion ; gastro-intestinal symptom > warmth. Note : In deep-seated, progressive, chronic diseases.