General features: Manganum is pre-eminently a drug that causes a species of chlorosis, and it is suitable for chlorotic girls, in broken down constitutions, waxy, anaemic, pallid, sickly, threatening phthisis, with necrosis and caries of bone and organic affections. There is the history of a long period of scanty menstruation, or the menses have been delayed until the patient was eighteen or twenty years of age. A strong feature is the great soreness of the periosteum, and especially of the shin bone. Tendency to ulceration and eruptions, and around these there is thickening and infiltration. Chronic eruptions; inveterate like psoriasis. Small ulcers suppurate and infiltrate with purple hardness. It has a deep action, breaks down the blood corpuscles and lays the foundation for tuberculosis, especially in the larynx. Repeated attacks of laryngitis, each leaving the patient in a worse state than before. Tuberculosis that begins in the larynx. Aversion to food, no appetite, nothing will tempt him. This, with great soreness over the body, lays the foundation for some deep complaint. It is not an acute periostitis, but a passive soreness all over. Inflammation of the joints and swellings go on to suppuration and necrosis. Ulcerations and suppurative processes take on a quality of semi-malignancy and do not heal, presenting an erysipelatous appearance. Everywhere there is soreness to touch and soreness from jarring. The bones are sore from walking. Arnica relieves only a day or two; but in this remedy it is deep-seated and prolonged, and we would not think of Arnica or Baptisia, which would only give relief for a day or so. Vesicular eruptions, infiltrating, deep-seated, with tendency to crack and bleed. Roughness of the skin and psoriasis. Complaints worse in cold, damp weather and before a storm.