Is the greatest of polychrests, because the bulk of its symptoms correspond in similarity with those of the commonest and most frequent of diseases. It is frequently the first remedy, indicated after much dosing, establishing a sort of equilibrium of forces and counteracting chronic effects. Nux is pre-eminently the remedy for many of the conditions incident to modern life. The typical Nux patient is rather thin, spare, quick, active, nervous, and irritable. He does a good deal of mental work; has mental strains and leads a sedentary life, found in prolonged office work, overstudy, and close application to business, with its cares and anxieties. This indoor life and mental strain seeks stimulants, coffee, wine, possibly in excess; or, again, he hopes to quiet his excitement, by indulging in the sedative effects of tobacco, if not really a victim, to the seductive drugs, like opium, etc. These things are associated with other indulgences; at table, he takes preferably rich and stimulating food; wine and women play their part to make him forget the close application of the day. Late hours are a consequence; a thick head, dyspepsia, and irritable temper are the next day's inheritance. Now he takes some cathartic, liver pills, or mineral water, and soon gets into the habit of taking these things, which still further complicate matters. Since these frailties are more yielded to by men than women. Nux is pre-eminently a male remedy. These conditions, produce an irritable, nervous system, hypersensitive and over-impressionable, which Nux will do much to soothe and calm. Especially adapted to digestive disturbances, portal congestion, and hypochondrical states depending thereon. Convulsions, with consciousness; worse, touch, moving. Zealous fiery temperament. Nux patients are easily chilled, avoid open air, etc. Nux always seems to be out of tune; inharmonious spasmodic action.