Preparation , Tincture of the inner bark. Authorities. 1 , Dr. Paine, "Concentrated Medicine," p. 85 (Dr. Hale, N. Am. J. of Hom., 1867, p. 391), effects of doses of 5 to 10 grains of "Populin" in a healthy person; 1 a , ibid., effects of 40 to 50 grains. General nervous excitement, [1a] . Slight fulness about the head, [1a] . Nausea, vomiting, and slight purging of bilious matter, with fierce, burning sensation in the stomach, [1a] . Warm, pungent sensation in the stomach, followed by a glow of heat on the entire surface, [1] . Very copious discharge of urine, and *irritation of the bladder and urethra , [1a] . Copious discharges of urine, [1] .