Biting or pungent pain; pain as if parts would burst, were pressed or pushed asunder. Pustulous exanthema, blue-colored. Waking too early in the morning. Affections of any kind of the external angles of the eyes; hypochondrium particularly about the spleen; lower region of the abdomen; palms of the hands. Worse.-- On entering a cold place; from spirituous liquors; with drunkards; when stretching the limbs; at changes of the temperature, whether from hot to cold, or vice versa . Remedies following:-- Bryon., Ignat., Kali carb., Nux vom., Rhus tox., Sepia .