Produces contraction of the unstriped muscular fibers; hence a constringent feeling throughout the whole body. This produces an anaemic condition, coldness, numbness, petechiae, mortification, gangrene. A useful remedy for old people with shriveled skin-thin, scrawny old women. All the Secale conditions are better from cold; the whole body is pervaded by a sense of great heat. Haemorrhages; continued oozing; thin, fetid, watery black blood. Debility, anxiety, emaciation, though appetite and thirst may be excessive. Facial and abdominal muscles twitch. Secale decreases the flow of pancreatic juice by raising the blood pressure (Hinsdale).