Imperfect assimilation and consequent defective nutrition. It goes further and produces neurasthenic states in consequence, and increased susceptibility to nervous stimuli and exaggerated reflexes. Diseases of bones, caries and necrosis. Silica can stimulate the organism to re-absorb fibrotic conditions and scar-tissue. In phthisis must be used with care, for here it may cause the absorption of scar-tissue, liberate the disease, walled in, to new activities (J. Weir). Organic changes; it is deep and slow in action. Periodical states; abscesses, quinsy, headaches, spasms, epilepsy, feeling of coldness before an attack. Keloid growth. Scrofulous, rachitic children, with large head open fontanelles and sutures, distended abdomen, slow in walking. Ill effects of vaccination. Suppurative processes. It is related to all fistulous burrowings. Ripens abscesses since it promotes suppuration. Silica patient is cold, chilly, hugs the fire, wants plenty warm clothing, hates drafts, hands and feet cold, worse in winter. Lack of vital heat. Prostration of mind and body. Great sensitiveness to taking cold. Intolerance of alcoholic stimulants. Ailments attended with pus formation. Epilepsy. Want of grit, moral or physical.