Among all our di'ugs this is the one of which we have the most different preparations. There is but one right kind. It is the pure poison, which is obtained by grasping the bee with a small forceps, and catching the mi- nute drop of virus suspended from the point of the sting, in a vial or watch crystal. After collecting a sufficient quantity it may be potentized in alco- hol, distilled water, or prepared in oil or pure glycerine, for external use It is absurd to dispute the solubility of the poison in alcohol, and foolish to take the whole bee with all the foreign matter and impurities, which color the tincture. In 1835 a clergyman in Thuringia, the Rev. Brauns, the publisher of the first popular homoeopathic paper, mentioned cures he had made with the pure poison of the honey bee, which he called Apisin. The same year he commenced a work, an attempt at treating homoeopathically domestic animals: Part I, horses, 1835; Part II, cattle, 1836; and Part III, sheep, 1843. A second edition of Part I was printed in 1837. He reported numerous cures with Apis, particularly of most obstinate diseases of horses. The great problem to be solved with regard to the snake poison (and of course also the nosodes), was: can we use the symptoms from inoculation, as well as the symptoms obtained by proving the alcoholic tinctures. It was thought that the proving of the bee-poison would solve the problem. In 1850 dried and powdered bees were introduced by E. E. Marcy, in his Theory and Practice. In January, 1852, we received a pamphlet containing real provings, by the New York Central Hom. Society, reprinted in the N. A. Quarterly, same year, p. 184 — 203, and Aug. 10, 1852. Tliis was translated into German, and numerous provings with the pure poison added ; also all notices of effects of the sting, that could be found, these being considered most important. The whole was printed in the form of a monography, in the Arnerikanische Arzneiprilfungen (American Provings), Vol. I, p. 171 — 422, and forms the most complete collection of the effects of any animal poison in medical literature. In 1858, Dr. C. W. Wolf published a book on bee-poison, declaring it a polychrest, but he also used the tincture from the whole bee. It happened, at the time to correspond to the genius epidemicus in Berlin, but Wolf recommended it in all intermittent fevers. His little book was translated in the same year and printed in New York; the author, however, was not allowed to add his notes, or he would have given the first provers in this country credit for what they had done. The greater number of confirmed symptoms were observed from the pure virus. ^ Mind. Loss of consciousness. Lost all consciousness of things around him, and sank into a state of insensibility. APIS. 378 Loss of consciousness in eruptive disease. iLoss of consciousness and delirium. ^Meningitis infantum. d Scarlatina. I Unconsciousness, stupor, with muttering delirium, d Typhus. 1 Sopor. ^Scarlatina. I i Sopor, interrupted by piercing shrieks. ^ Tubercular men- ingitis. I Child lies in torpor. ■ Impaired memory. ^Prosopalgia. B I Absent-mindedness. I Lets everything fall out of her hand, or breaks things and laughs over it. 6 Amenorrhoea. ■ Very busy; restless, changing kind of work, with awkward- ness, breaking things ; lets everything fall out of his hands. Dullness of mind. Difficulty of thinking. ■ Could not bring his thoughts to bear upon anything definite. d Diarrhoea. I I Cannot bring his thoughts to bear on any subject continu- ously. Imbecility, more frequent than insanity. ■ Thinks he will die. ^Organic disease of heart. A strange boy lying in bed with him prevents sleep. 6 Typhus. I I Anticipation of death. ■ After midnight, slightly delirious. ^Typhus. I I Delirium : with congestion ; eruptions ; heat ; during sleep. ■ Slightly delirious. ^Diphtheria. ■ Muttering delirium. ^Measles. ■ Delirium. ^ After suppressed scarlet eruption. ^Amenor- rhoea. ■ Muttering delirium alternating with stupor, d Cancer of mamma. ■ Violent delirium, amounting to phrenzy. d Paralysis. Mania. ■Nymphomania. ■ ■Manias, especially proceeding from a sexual cause in women. Insanity, particularly nymphomania and apathy depending on or alternating with sore throat, indigestion or bladder affections. Loquacity. Happy expression. " ■Acts foolishly or with a good deal of frivolous levity. 6 Hysteria. I I Busy, frivolous, disposed to laugh, excessively cheerful. ■ Muttering. ^Gastroenteritis. ■ Continual moaning and screaming. ^Diarrhoea. ■ Sudden thrilling cries. ^Hydrocephalus. ■ Shrill screaming " oh my baby." d Pneumonia. ■ Crying out and screaming loudly as from stabbing pain. d Cerebro-spinal meningitis. 3T9 , APIS. I Screaming spells. 6 Dysentery of infants. I Sudden sharp outcry during sleep. ^Scarlatina. ■ Children scream out suddenly and sharply during sleep, most at night; if asked what hurt them, they reply "nothing." 6 Dentition. I Single sharp shrill screams while sleeping or waking. 6 In- cipient meningitis. I B Shrill, sudden piercing screams. 6 Hydrocephalus, pneumo- nia, and many other complaints. i Scream out very sharply and shrilly during sleep or when awake, "crie cerebrale." ^Encephalitis. ■ Shrieking. 6* Eclampsia. ■ Violent shrieking and screaming spells at longer or shorter in- tervals, d Infantile marasmus. ■ ■Great tearfulness, cannot help crying. ■ Constantly busily engaged doing this or that, but do nothing right ; young girls, d Amenorrhoea. ■ Cannot bear to be left alone. 6 Organic disease of heart. ■ Dreamy and indolent. ^ Acute Bright's disease. ■ Feels too lazy to get the water, but thirsty. ^Catarrh of