In poisonous doses paralyzes the heart and respiration ; its profound collapse may be associated with profuse alvine evacuations, cold sweat, feeble pulse and labored breathing, but always with terrible anguish . It causes peripheral anaesthesia and excites most intense neuralgia, particularly in the nerves of the face ; pains are sharp, sticking ; general hyperaesthesia, dryness of mucous membranes, bright haemorrhages. It produces and cures febrile conditions only with extreme anguish, restlessness and thirst, never with apathy ; a high temperature is not by itself an indication for Aconite. Rarely useful in any form of malarial fever. In the earliest stage of inflammatory conditions, even during the chill, it is invaluable, provided the characteristic deathly anxiety be pronounced. It is found valuable for the remote as well as recent effects of fright and other shocks to the nervous system. The special senses are all extremely acute. Inflammation of mucous membranes in earliest stage ; they are dry, hot and exquisitely tender. It is particularly valuable at the beginning of many inflammatory affections of the thoracic organs, anguish, difficult breathing, sharp pains, et cetera . These general indications may be applied to a variety of troubles, for its sphere of action is quite general.