The inspissated juice, root and bark have been extensively used in the East for their emetic, sudorific, alterative, and purgative qualities. The fresh juice is considered a valuable remedy in skin affections. A short proving brought out the following symptoms: Weak, tired feeling; coldness; dizziness; pain and confusion in head; nausea and vomiting of bile; frequent micturition; pain, soreness, and redness of thigh pain in both legs, swelling of knees, stiffness and inability to walk pains in hands and feet; first left then right, pains < movement or putting weight on them. Dr. Gramm, of Philadelphia (Minn. H. Mag., Aug., 1897), has used the tincture with great success in cases of syphilis when Mercury can no longer be given; in the anaemia of syphilis; secondary syphilis. A sense of warmth in the scrobiculus cordis is a leading indication for the remedy.—In one case of severe and advanced syphilis, with enormous thickening of the ends of all the nails, Calo. effected a cure. The remedy was given in one- to five-drop doses of the tincture, or in pellets saturated with equal parts of the tincture and 95 per cent. alcohol.