Acts upon the intestinal canal, producing irritation, and giving rise to a train of symptoms closely resembling those which indicate chronic irritation, inflammation, and the presence of intestinal worms. It also acts upon the brain and other organs, but these are only secondary to the primary irritation of the bowels. Santonin , the active principle of Cina , is often used in its stead, its characteristic action being the same, though possibly somewhat more uniform and intense. The leading expression of Cina is peevishness. Characteristic symptoms.