Coffea irritates the cerebro-spinal nerves, producing excitation of the special senses and of all the organic functions, the former becoming highly acute and sensitive, and the nervous activity of the latter morbidly increased. Hence the general condition is one of high nervous excitement, or exaltation of both mind and body, both cerebral and organic manifestations. Therefore, we find its chief characteristics to be a morbid excitation of the special senses, great sensitiveness to pain, and sleeplessness from excitement, one or more of which conditions are always present. Characteristic symptoms.