Eupat. perfol. is an old-world remedy, having been recommended by Dioscorides for ill-conditioned ulcers, dysentery, stings of reptiles, chronic fevers, obstructed liver. The leading characteristic for its homoeopathic use is the distressing bone-pains it causes, such as are found in connection with malarial fevers and influenza. Soreness will be found running throughout the proving: headache with soreness internally, parietal protuberances sore; with pain and soreness in eyeballs; cough with extreme soreness down trachea, soreness of chest, aching in limbs throughout the body. A characteristic cough of Eup. perf. has > by getting on hands and knees. W. P. Defriez reports a case in point: Every winter for several years the patient had been annoyed by a dry, hacking cough, with paroxysms lasting some time, only relieved by getting on hands and knees. Eupat. Perfol. cured. The chills of Eu. perf. begin in the small of the back, with aching in the limbs as though every bone in the body were being broken; high fever with increased aching, followed by sweat scanty or profuse; sweat > all pains except headache, which is <. Periodicity is marked. There may be a double periodicity: Chill morning one day, evening the next. The liver is strongly affected by Eup. perfol.; bilious vomiting and diarrhoea; bilious sick-headaches; cough arising from irritation of liver. Catarrhal symptoms are prominent. Nocturnal loose cough. Hoarseness with aching soreness of trachea. Hoarse, rough cough with scraping in bronchia. Cough with soreness, compelling the patient to hold his chest with his hands. Stiffness and general soreness. Cannot twist body either while standing, sitting, or lying. Cannot lie in bed on account of a feeling as if every bone was bruised, causing despair, moaning, and crying out. Bone-pains of all descriptions appear under Eupat. perf. Sleepiness and yawning. Sensation as if falling to left. Pain and extreme tenderness of left glutei muscles. Hale describes the fever of E. perfol. as follows: "The chill is nearly always in the morning, and is preceded for several hours by thirst, soreness and aching of the bones. The thirst continues during the chill and heat. The chill is attended by nausea, vomiting of bile, intense aching and soreness in the flesh of the extremities, and often all over the body. These symptoms continue during the heat, especially the vomiting, which is often painful and incessant. The heat is apt to be prolonged until evening or into the night, and may be followed or not by sweat (with chilliness). If no sweating occurs the apyrexia is short and attended by chilliness, nausea, thirst, and debility, showing that the febrile action never altogether subsides, giving a true type of Remittent fever—a fever in which Boneset is often our best remedy, especially if occurring in summer and autumn, and is attended by very severe bilious symptoms." Lying on back < cough. Kneeling with face towards pillow > cough. Rising up > headache. Eating = violent distressing pains which are only relieved by vomiting. There is intense thirst, but drinking cold water = shuddering and vomiting of bile. Chilliness predominates, wants to be covered; > in house, < in open air; < after being in ice-house. I have found Eup. perf. most useful in influenza.