Eupatorium perfoliatum is of use in rheumatic affections accompanied by perspiration and great soreness of the muscles and bones. The intense, intolerable aching deep in the muscles and bones, with a sensation of soreness as if the parts had been beaten or the bones broken, < by motion and in the morning, makes a clear picture that suggests Eupatorium, under whatever circumstances it may be found. Compatible with Nux vomica and Sepia, and both follow well.