Berridge has recorded these two symptoms caused by a 15-grain dose: (1) Uninterrupted sensation as if an immense load were on entire upper portion of head, causing a gloomy apprehensiveness of congestive apoplexy (lasted three days, removed by a dose of Nux 1). (2) Heat from or heat at cardiac orifice of stomach lasting 12 hours; unaffected by food or drink.