Anxiety: This remedy in all of its complaints whether acute or chronic, has a peculiar kind anxiety that is felt both in mind and body. It seems also that this state of anxiety is attended with a thrill that goes throughout his frame unless he removes it by motion or change of position. The anxiety comes on when trying to keep still, and the more he tries to keep still the more the anxious state increases. While attempting to keep still, he is overwhelmed with impulses, impulses to tear things, to kill himself, to commit murder, to do violence. He cannot keep still and so he walks night and day. This remedy carries the same feature with it into the Iodide of Potassium, so that it makes the Iodide of Potassium patient walk. But there is this difference, the Kali iod. patient can walk long distances without fatigue, and the walking only seems to wear off his anxiety, whereas in Iodine there is great exhaustion; he becomes extremely exhausted from walking and sweats copiously even from slight exertion. Iodine corresponds to those cases in which it seems that there is some dreadful thing coming on; the mind threatens to give out. Insanity threatens, Or the graver forms of disease are threatening, such as are present in the advanced stages of suppressed malaria, in old cases of chills, in threatened phtysie, especially abdominal. Hypertrophy: runs through the remedy. There is enlargement of the liver, spleen, ovaries, testes, lymphatic glands, cervical glands, of all the glands except the mammary glands. The mammoe dwindle while all other glands become enlarged, nodular and hard. This enlargement of the glands is especially observed among the lymphatic glands of the abdomen, the mesenteric glands. There is this peculiar circumstance also in Iodine, viz., that while the body withers the glands enlarge. That is peculiar and will enable you to think of Iodine, because the glands grow in proportion to the dwindling of the body and the emaciation of the limbs. We find this state in marasmus. There is withering throughout the body, the muscles shrink, the skin wrinkles and the face of the child looks like that of a little old person, but the glands under the arms, in the groin and in the belly are enlarged and hard. The mesenteric glands can be felt as knots. We see the same tendency in old cases of malaria coming from the allopaths in which Quinine and Arsenic have been extensively used and the chills have kept on; the face and the upper part of the body are withered, the skin looks shriveled and yellow; a diarrhoea has come on, the liver and spleen are enlarged and the lymphatic glands of the belly can be felt. Even in the earlier stages, when these states are only threatening, we may look forward and see that the case is progressing toward an Iodine state. Now take a patient that is suffering from intermittent fever brought on from malaria, or damp cellars. The patient grows increasingly hot; it is not always a febrile heat, but a sensation of heat; he wants to be bathed in cold water, wants the face and body cooled by cold sponging; he suffocates and coughs in a warm room, dreads heat, sweats easily and easily becomes exhausted. It is in this kind of a constitution that acute complaints will come on, such as acute inflammatory conditions of the mucous membranes and gastritis, inflammation of the liver, inflammation of the spleen, diarrhoea, croup, inflammation of the throat. The throat even becomes covered with white spots and is tumid and red, and ibis extends down into the larynx; it may even have a deposit upon it like diphtheria. Iodine has cured diphtheria, when the exudation resembling the diphtheria exudations, was present in the stool. A constitution tending this way may bring on croup with an exudate, and we can see that it is going towards Iodine. In every region of the body peculiar little things come out. If we do not see to the full extent the constitution of the remedy, we will not recognize the tendency of the patient, when progressing unfavorably.