Great general weakness; feeble reaction; extreme sensitivity, and nervous trembling, are marked features in this remedy. Patients greatly broken by long suffering, pain and sickness, physical more than mental suffering, finally anemia and emaciation are marked. Sensitive to cold; always chilly. Symptoms are aggravated from becoming cold, and in cold air. Always taking cold. The walls of blood vessels are relaxed and bleed easily; profuse dark blood. Pains as if flesh were torn from the bones and a sensation as though a splinter felt in inflamed parts, in ulcers and in nerves. Inflammation of the periosteum, in bone, and in the nerves. Syphilitic bone pains. Caries of bone, and exostoses. The margins of orifices bleed and grow warts. Old scars become painful in cold weather and when weather changes to cold; pains like splinters. Inflammation of glands after the abuse of mercury in syphilitic subjects. Prolonged suppuration in glands, with no tendency to repair, when there are sticking pains. The discharges are thin, bloody, offensive and excoriating; sometimes a dirty yellowish green. Suppuration where there is no tendency to repair. This is often the case when the patient is syphilitic and has been surcharged with mercury. For suppuration and ulceration in cancerous affections with bloody, watery, offensive discharges and sticking pains. It has often been observed that the patient requiring Nitric acid is more subject to diarrhea than constipation. It has cured many complaints in patients who are never so comfortable as when riding in a carriage. Twitching of muscles in all parts of the body. Many complaints are aggravated from a jar, and from noise. Even his pains are aggravated from noise. Nitric acid patients are often extremely sensitive to medicines, especially high potencies indeed, they prove every remedy given too high. Fissures form in many places; canthi, corners of the mouth, above the anus; the skin cracks - and all these have the splinter sensation. He finally becomes dropsical, especially in the extremities. Offensiveness is a marked condition of this patient, often putrid odors. The urine smells like that of a horse. Offensive leucorrhoea, offensive catarrh, and breath; foetid foot sweat. Strong odors from the body. Too much weight must not be given to the dark, swarthy complexion so often mentioned as the one most likely to need this remedy. Nitric acid will cure blondes as often as brunettes, if the symptoms agree.