Affects especially the portal, hepatic, and the female sexual systems, and diminishes in general the reproductive energies of the vegetative sphere. Its action is sluggish, and its pains and isolated symptoms feebly pronounced, the general condition being one of torpidity and depression. The functions of the liver are not greatly disturbed, but the secretions are altered, becoming sour and foul, and the texture changed, as is indicated by a special analysis of the symptoms produced. Sepia exerts its chief local action upon the mucous membranes of the genito-urinary organs, and upon the skin. The leading expression of Sepia is a peculiar cachectic aspect-yellow, earthy, waxy complexion, with puffiness of the soft parts, and with mental depression and apathy. Characteristic symptoms.