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Tuberculinum

TUB · 7 λήμματα σε 6 βιβλία
Βιότοποςhuman. Παρασκευήextract of a pure cultivation of tubercle bacilli (human). attenuations. Clarke
3X, 5X, 2X, 6X, ↑
Το Tuberculin χρειάζεται συχνότερη επανάληψη στις παιδικές παθήσεις από σχεδόν κάθε άλλο χρονίο φάρμακο (H. Fergie Woods). Τριακοστή και πολύ υψηλότερη, σε αραιές δόσεις. Όταν το Tuberculinum αποτυγχάνει, το Syphilinum συχνά ακολουθεί με όφελος, προκαλώντας αντίδραση. «Η χρήση του Tuberculinum στη φθισική πνευμονία απαιτεί προσοχή στα εξής σημεία: Στην άπυρητη καθαρά φθισική φθίση τα αποτελέσματα είναι εντυπωσιακά, εφόσον τα οργάνα αποβολής λειτουργούν καλά, αλλά τίποτα κάτω από τη 1000ή δεν πρέπει να χρησιμοποιείται, εκτός αν είναι απολύτως απαραίτητο. Σε ασθενείς όπου υπάρχουν στρεπτο-σταφυλο-πνευμονόκοκκοι στους βρόγχους· όπου επίσης, μετά το πλύσιμο των πτυέλων, παραμένει καθαρή μάζα βακίλλων «t b.», η ίδια θεραπεία ενδείκνυται. Στη μικτή λοίμωξη —που βρίσκεται στην πλειονότητα των περιπτώσεων— όπου τα πτύελα σφύζουν από παθογόνους μικροοργανισμούς επιπλέον των «t b.», άλλη διαδικασία είναι αναγκαία. Αν η καρδιά είναι σε καλή κατάσταση, χορηγείται μία δόση Tuberculinum 1000-2000, εφόσον δεν υπάρχουν έντονες ενδείξεις για άλλα φάρμακα. Με δέουσα προσοχή στη θερμοκρασία και στις πιθανές εκκρίσεις, η δόση αφήνεται να δράσει μέχρι να μη παρατηρούνται πλέον αποτελέσματα, από οκτώ ημέρες έως οκτώ εβδομάδες. Συνήθως εμφανίζεται τότε ένα σύνδρομο, που επιτρέπει την ακριβή επιλογή ενός αντιψωρικού Silica, Lycopodium, Phosphorus κ.λπ. Μετά από λίγο η εικόνα σκοτεινιάζει πάλι και τώρα χορηγείται υψηλή δυναμοποίηση του ισοπαθητικού φαρμάκου που αντιστοιχεί στον πιο παθογόνο και εμφανή μικροοργανισμό που βρίσκεται στα πτύελα: Staphylo-Strepto- ή Pneumococcin. Η ακριβής βακτηριολογική ανάλυση των πτυέλων είναι απολύτως απαραίτητη· η επιλογή του ισόν ξανακαθαρίζει την εικόνα, και έτσι, προχωρώντας από τη μία πλευρά αιτιολογικά (όπου αυτά τα ισοπαθητικά δεν έχουν ακόμη πειραματιστεί)· από την άλλη πλευρά συμπτωματικά με αντιψωρικά φάρμακα, η νόσος κυριαρχείται. Η δική μου εμπειρία προειδοποιεί, στην περίπτωση μικτής λοίμωξης, κατά της χρήσης Strepto-, Staphylo- ή Pneumococcin κάτω από την 500ή. Τα χρησιμοποιώ μόνο από 2000 έως 1000, έχοντας δει τρομερές επιδεινώσεις από τις 30, 100, 200, με πτώση της θερμοκρασίας από 104 έως 96. Επομένως η προειδοποίηση, που δεν χρειάζεται να αφορά τους ειρωνολογούντες, αλλά μόνο εκείνους που επιθυμούν να αξιοποιήσουν ένα ισχυρό όπλο. Οι τοξίνες που χρησιμοποιούνται ως φάρμακα είναι, όπως το Tuberculinum, παρασκευασμένες από καθαρές και παθογόνες καλλιέργειες. Και περιπτώσεις, φαινομενικά καταδικασμένες σε ταχύ θάνατο, επανέρχονται σε ένα ή δύο χρόνια σε φυσιολογική θερμοκρασία, αν και, φυσικά, με θυσία μεγάλου μέρους του πνευμονικού ιστού. Αυτό το αποτέλεσμα είναι βέβαιο όταν ο ασθενής μπορεί και θέλει να φροντίσει τον εαυτό του, όταν η καρδιά έχει αντέξει την τοξίνη και το στομάχι και το ήπαρ λειτουργούν καλά. Επιπλέον, οι κλιματικές μεταβολές πρέπει να αποφεύγονται. Με τον μεγάλο ορυκτό μεταβολισμό του φθισικού, η ρύθμιση της δίαιτας είναι επιτακτική, και πρέπει να είναι κυρίως φυτική, μαζί με την προσθήκη φυσιολογικών αλάτων σε χαμηλή δυναμοποίηση, Calcarea carb, 3x, 5x, Calcarea phos, 2x, 6x, και διαλείποντως σύμφωνα με ενδείξεις οργανο-φάρμακα όπως Cactus Tr. 30, Chelidonium Tr. 30, Taraxacum Tr, Nasturtium Tr, Urtica urens Tr, Tussilago farfara Tr, Λυσιμάχεια η νουμουλάρια Tr, για σύντομα διαστήματα. Η πρώτη δόση του Tuberculinum σε κάθε δύσκολη περίπτωση είναι, ωστόσο, η πιο βαρυσήμαντη συνταγή. Το φάρμακο δεν πρέπει να χορηγείται χωρίς εξαιρετικά προσεκτική καρδιακή εξέταση. Όπως ο χειρουργός πριν από την αναισθησία, έτσι και ο ιατρός πρέπει να γνωρίζει την καρδιά πριν χορηγήσει αυτό το φάρμακο, ιδίως σε παιδιά και ηλικιωμένους —και σε νεαρούς ηλικιωμένους. Όποιος τηρεί αυτόν τον κανόνα θα έχει λιγότερες κλινικές μεταμέλειες στη συνείδησή του. Όταν το Tuberculinum αντενδείκνυται, πρέπει να γίνεται προσφυγή στο πλησιέστερο αντιψωρικό. Η παραπάνω προσοχή ισχύει επίσης για το άσθμα, την πλευρίτιδα, την περιτονίτιδα σε σκοφουλώδη (φθισικά) άτομα.» (Δρ. Nebel Montreux)Δόση · Boericke

Λόγος χρήσης

Fragmentary provings by Swan, upon M. B. B. with cm. ; Edna Eose, with cmm.

Authorities : — Refer to New Organon, July, 1879, pp. 342, 439, 449 ; Swan's Morbific Products, 1886; Burnett's New Cures, 1885 to 1890; J. A. Biegler's Eeport; C. F. Nichol's paper in Popular Science News, April, 1891.

Clinical Authorities. — Tubercular meningitis, Biegler, Org., vol. 2, p. 439 ; Horn. Phys., vol. 11, p. 187; Burnett, Consumption, pp. 9, 13, 31, 53; Chronic headache, Swan, Org., vol. 3, p. 41 ; Vomiting, Kent, MSS. ; Tabes mesenterica, Burnett, Consumption, pp. 52, 82 ; Cholera infantum, Swan, MSS. ; Cough, Board- man, Org., vol. 2, p. 448 ; Burnett, Consumption, p. 15 ; Threatened phthisis, Incipient tuberculosis, Burnett, Consumption; Tubercular synovitis of knee, Burnett, Consumption, p. 47 ; Spasms, Swan, Organon, vol. 2, p. 342; Horn. Phys., vol. 11, p. 187 ; Ringworm, Burnett, Consumption, pp. 96-100.

^ Mind. ' I Although naturally of a sweet disposition, became taciturn, sulky, snappish, fretty, irritable, morose, de- pressed and melancholic, even to insanity. ^Tubercu- lar meningitis. Burnett.

I I Fretful, ailing, whines and complains ; mind given to be frightened, particularly by dogs. ^Hydrocephaloid. Burnett. ^ Inner Head. TrSevere headache, < on second day, lasting until third, recurring from time to time for many weeks and compelling quiet fixedness. Burnett.

I Headache, with frequent sharp, cutting pains passing from above r. eye through head to back of 1. ear. Rose.

1 I Headache of great intensity preceded by a shuddering chill passing from brain down spine ; with attack a feel- ing as if head above eyes were swollen ; became uncon- scious with screaming, tearing her hair, beating her head with her fists or trying to dash it against wall or floor. Swan.

I I Headache of forty-five years' standing, pain passing from r. frontal protuberance to r. occipital region. Swan.

I I Terrible pain in head, as if he had a tight hoop of iron around it ; trembling of hands ; distressing sensation of damp clothes on his spine; almost absolute sleepless- ness ; profound adynamia ; was thought by his friends to be on verge of insanity ; most of his brothers and

351 TUBERCULINUM.

sisters had died of water on brain ; r. lung solid, prob- ably from healed-up cavities, as he at one time suffered from pulmonary phthisis. Burnett.

I I Sullen, taciturn, irritable, screams in his sleep, is very restless at night, costive ; sister died of tubercular men- ingitis. Burnett.

I I Fretful and ailing, whines and complains, indurated glands can be felt everywhere, child hot, drowsy, urine red and sandy, much given to be frightened, particu- larly by dogs ; was vaccinated and had a very bad arm for four months thereafter; would not smile, whimpers when spoken to, skin dingy, skull hydrocephalic. Bur- nett.

I I Boy, set. 20 months, ill for days with head, high fever, restlessness and constant screaming ; finally no sleep for forty hours, followed by a condition of collapse ; peculiar smell of body ; family histor}'- of tuberculosis. Burnett.

I I Tubercular meningitis, with effusion ; head greatly en- larged ; alternately wakeful and delirious at night, talked nonsense by day, at intervals; nocturnal hallu- cinations and fright; delirium; pyrexia; had eczema which almost disappeared after two unsuccessful vacci- nations, and which were soon followed by above condi- tion ; after administration of remedy there occurred a severe pustular eruption, then patches of a lepra and eczema appeared. Burnett.

I I Basilar meningitis. Sinker.

■ Tubercular meningitis. Sinker.

I I Acute cerebral meningitis, with intense strabismus. Biegler. ^ Smell and Nose. Soreness inside of nose, commencing as watery pimples, which, suppurating, form scabs; nose and lips somewhat swollen; itched slightly. Rose. ^ Lower Face. Slight swelling and itching of lips. Rose. '^ Hiccough, Belching, Nausea and Vomiting. Nausea be- fore breakfast, with sudden diarrhoea. M. B. B.

i I Frequent vomiting. Kent. *^ Scrobiculum and Stomach. 1 1 Windy dyspepsia, with pinching pains under ribs of r. side in mammary line. Burnett. ^^ Abdomen, i ' Fever, emaciation, abdominal pains and dis- comfort, restless at night, glands of both groins enlarged and indurated ; cries out in sleep ; strawberry tongue. ^Phthisis. Burnett.

I 1 Tabes mesenterica; swelling on 1. side, also on r. ; com- plains of a stitch in side after running; languid and indisposed to talk; nervous and irritable; talks in his

TUBERCULINUM. . 352

sleep, grinds his teeth ; appetite poor ; hands blue ; in- durated and palpable glands everywhere; a drum belly, spleen region bulging out. Burnett.

I I Inguinal glands indurated and visible; excessive sweats; chronic diarrhoea. ^Tabes mesenterica. Burnett. ^" Stool and Rectum. Sudden diarrhcea before breakfast, with nausea.

I I Diarrhoea, furious fever, burning hot skin, great heat in head, red, flushed face, eyes turned upward, quivering and rolling ; peculiar fetid smell of body. ^Incipient tuberculosis. Burnett.

I I Cholera infantum. Swan.

I I Severe hemorrhages from bowels, cough; emaciation; family history of phthisis. Burnett. "" Cough. I I Slight tedious hacking cough, which had lasted for months in a girl of a distinctly phthisic habit. Burnett.

1 I Hard, dry cough, sometimes slight, but generally no expectoration, slightly feverish. Boardman.

I I Hard, dry cough, shaking patient, more during sleep, but did not waken him. Boardman.

I I Expectoration of non-viscid, very easily detached, thick phlegm from air passages, followed after a day or two by a very clear ring of voice. Burnett. Inner Chest and Lungs, i i Slight hacking cough, contin- uing all day, < at bedtime and on rising ; emaciation ; dulness on percussion at apex of r. lung. ^Threatened phthisis. Burnett.

I I Girl, set. 15, tall for her age ; tonsils enlarged ; chronic discharge from nose, < early morning on rising; speech thick ; thorax of pigeon-breast type ; menstruated freely ; perspires much across nose; very bad perspiration of chest, armpits, palms, nose and feet; feels very chilly; spleen swollen ; distinct dulness on percussion at apex of r. lung; suffered badly from vaccination; gets chil- blains. ^Incipient tuberculosis. Burnett.

I I Hectic flush of cheeks; shortness of breath; slight hacking cough ; several strumous scars on neck ; dusky skin ; large, moist rales in both lungs ; increased vocal resonance of r. lung; amphoric sounds in r. lung; large, soft-feeling gland in 1. side of neck; very pronounced endocardial bruit, best heard at apex beat {lodoformum 3x in four grain doses for two months, with improve- ment, followed by Tuherculinum c. in very infrequent doses). Burnett.

I I Incipient phthisis in a boy set. 7; loss of flesh; great prostration; morbid timidity; glands of groins and on both sides of neck very much enlarged and indurated,

353 TUBERCULINUM.

particularly glands over apex of r. lung; as he had suf- fered much from vaccination, Thvja 30 and Sahina 30 were first given, then Tuberculinum c. Burnett.

I I Nocturnal perspirations; notched incisors; indurated glands everywhere, very large and numerous; drum- bellied; grinding of teeth at night; great susceptibility to taking cold ; perspiration < at back of lungs and on head ; big head, with bulging forehead ; subject to attacks of fever and diarrhoea. ^Incipient phthisis. Burnett.

M Incipient tubercular disease; restless at nights; sleep- less; grinds teeth; tendency to diarrhoea; want of appe- tite; foul breath; notched teeth; pain after food; vom- iting of food; indurated glands; strawberry tongue; naughty; very irritable temper; puny growth; very thin; girl, set. 6. Burnett.

I I A nasty little cough for seven weeks; much expectora- tion; pains in r. lung; evening fever; liver and spleen enlarged; cough < morning after breakfast; neck slightly goitrous; eats hardly any breakfast. Burnett.

I I Cough, < 6 A.M.; notched incisors; thin and puny; cer- vical and inguinal glands much enlarged and indu- rated; strawberry tongue; girl, set. 7. ^Incipient phthisis. Burnett.

I I No respiratory sounds at top of r. lung, and vocal reso- nance slightly increased ; pain in 1. side ; profuse per- spiration; girl, set. 18. Burnett.

I I Much fever, < evenings; restless and terribly irritable; much depressed and in almost constant agitation ; tongue very red ; chronic diarrhoea; has lost fourteen pounds during last six weeks; has no appetite; evacuations dis- charged from bowels as from a pop-gun. ^Threatened phthisis. Burnett.

I I Bad cough of about twelve months' duration; expecto- ration of blood; one of apices was audibly diseased ; has had pneumonia; chest flat; respiration accelerated; tanned unduly in sun. Burnett.

I lAnsemic,sickly, pale; profound debility; dyspnoea, can- not mount or hurry; menses irregular. ^Phthisis pul- monum. Burnett.

I I Lady, set. 26, in first stage of consumption; dyspnoea and rapid breathing; loss of flesh; greasy, dingy skin. Burnett.

I I Stout man, bright, florid complexion, mother died of phthisis, with which disease her sister is suffering; gets pneumonia very often in cold weather; hence travels

. from place to place to avoid colds; coughs much, brings up much phlegm; perspired profusely and drank great quantities of fluids; wretched sleepless nights, with

VOL. X.— 23.

TUBERCULINUM. 354

almost constant fever; glands of neck much enlarged. /^Phthisis. Burnett. I I Complains that she has been in consumption for many years; is very thin and consumed with fever; lungs very fiat; respiration almost imperceptible; fever; poor appe- tite; languid. Burnett. I I Ringworm on scalp; lymphatic glands everywhere pal- pable; ribs very flat; strawberry tongue, bad cough, < at night; although 11 years old she had practically no teeth, they were rudimentary, and not above level of of gums. Burnett. I I Pronounced phthisical habit; severe piles; constipation; brown cutaneous affection on abdomen. Burnett. ^' Neck and Back, i ' Indurated cervical glands.

Lump size of a walnut on cord of neck, is movable and occasionally itches. Rose. ^' Lower Limbs. Lame feet for three weeks, would walk or stand on sides of feet to rest them. M. B. B.

Cramps in calves. M. B. B.

I I Tubercular swelling of knee; intermittent attacks of pain in it; has expectorated clots of blood and suffered from exhausting sweats; family history of phthisis. Burnett.

I ' Tuberculous disease of 1. knee ; for eleven months had been limping; knee much enlarged and very tender; teeth dirty and carious; strawberry tongue. Burnett.

I I Tubercular synovitis of 1. knee. Burnett. ^^ Nerves, l l Suddenly became unconscious while sewing or talking, began screaming, tearing her hair, beating her head with her fists, or trying to dash it against wall or floor; attacks daily, for a month, then spasms set in, with rolling of head from side to side and moaning; continuing five weeks, followed b}^ a recurrence of faint- ing fits, at least twice a week; a few hours before an attack of fainting, a shuddering like a chill seemed to go from brain down spine ; when questioned about an attack, she said head would suddenly seem to swell over eyes and pain became " horrid," and she knew no more ; between attacks she was free from all complaints except fatigue and an ever-present frontal headache. Swan. '^'' Sleep. J)isturbed, distressful sleep. Burnett. ^^ Time. Morning: before breakfast, sudden diarrhoea; on rising, hacking cough < ; on rising, discharge from nose < ; after breakfast, cough <.

6 A.M. : cough <.

Evening: at bedtime, hacking cough <; fever.

All day: hacking cough.

Might: wakeful and delirious; restless; grinding of teeth; cough <.

355 TU BERCULINUM.

'"Fever, l l Fever. (?Phtbisis. Burnett.

*' Attacks, Periodicity. Intermittent attack : of pain in

tuberculous knee. For forty hours : no sleep. Twice a week : fainting fits. For three weeks: lame feet. During six weeks : lost fourteen pounds. For seven weeks: a nasty little cough. For eleven months : limping, from tubercular knee. For about twelve months : a bad cough. For forty-five years : headache. "Locality and Direction. Left: enlarged gland on neck;

pains in side; tuberculous knee. Right : sharp pain above e3^e, through to 1. ear ; pain from

forehead to occiput ; pinching pains under ribs; dulness

in apex of lung ; increased vocal resonance in lung ;

amphoric sounds in lungs ; pain in lung. *^ Sensations. As if head, above eyes, were swollen, followed

by unconsciousness ; as if he had a tight hoop of iron

around head; as of damp clothes on his spine; a shud- dering like a chill seems to go from brain down spine. Terrible pain : in head.

Cutting : from above r. eye, through head to back of 1. ear. Stitch : in 1. side, after running. Pinching: under r. ribs. Cramps: in calves.

Itching: of nose and lips; in lumps on neck. *^Skin. I (Very bad tempered ; very much pigmented where

sun's rays impinged upon him; teeth dirty, greenish.

^Phthisical habit. Burnett. Eruption of itching blotches all over bod}^, with exception

of face and hands. Rose. ■ Ringworm. Burnett. *^ Stages of Life, Constitution. Boy, set. 15 months, dark, fat,

sister died of consumption of brain ; incipient tubercular

meningitis. Boy, set. 20 months ; threatened tubercular meningitis. Boy, set. 2 years and 8 months, brother of two children

w^ho died of tubercular meningitis ; tuberculosis. Boy, set. 3 ; incipient tuberculosis. Girl, set. 6, daughter of a countr}^ squire who was suffering

from chronic phthisis; phthisis. Girl, set. 7 ; incipient phthisis. Girl, set. 7, family history of phthisis ; tubercular affection

of knee. Boy, set. 7, family history of phthisis ; incipient phthisis. Boy, set. 8, family history of consumption ; threatened

phthisis.

TUBERCULINUM. 356

Boy, set. 10; tabes raesenterica.

Girl, set. 11, family history of phthisis ; ringworm, carious teeth, cough, etc.

Girl, set. 1 3, overgrown ; phthisis.

Boy, set. 14 ; phthisis.

Girl, set. 15; incipient tuberculosis.

Girl, set. 17, sister died of consumption ; phthisis.

Girl, set. 19 ; pulmonary phthisis.

Girl, set. 20, phthisic habit, tall for her age, long fingers, almond-shaped nails, long neck, indurated glands in neck; cough.

Lizzie R., set. 21, when three years old was frightened into a fit, which was followed by chorea, which continued until she was thirteen ; has never been in good health ; for the last four or five years passed through a variety of conditions, at one time being confined to bed for six- teen months, during nine months of this time could eat nothing but ice-cream ; then had an attack of trismus, followed by severe ulceration of mouth; finally spasms set in, and after these ceased she passed through a con- dition simulating last stage of phthisis ; spasms.

Lady, set. 22, single, delicate habit of body, brother has consumption of bowels ; threatened phthisis.

Lady, set. 26, single, family history of consumption ; phthisis.

Merchant, set. 26, tall, slim, long, thin neck, bends forward, both parents died of lung disease ; incipient phthisis.

Man, set. 30, married, ten of his relations died of phthisis ; tubercular swelling of knee.

Woman, set. 38, mother of seven children, three sisters died of consumption ; threatened phthisis.

Lady, set. 40, single ; phthisis.

Lady, set. 40, married, family history of consumption ; threatened phthisis.

Man, set. 50, family history of phthisis; hemorrhage from bowels.

Man, set. 50, an author of eminence, well known in theo- logical circles, brother and sister died of water on brain, r. lung solid, probably from healed-up cavities, he hav- ing by treatment and travel "grown out" of his pulmo- nary consumption ; tubercular meningitis.

Lady, set. 50, fiorid, mother and six brothers and sisters died of consumption ; tubercular synovitis.

Gentleman, ver}'^ big and stout, of bright, florid complexion, family history of consumption ; phthisis. *^ Relations. Complementary: Hydr. can. to fatten patients cured with TubercuUnum.

357 URANIUM NITRICUM.

Πλήρες κείμενο του λήμματος Tuberculinum στο Hering - Guiding Symptoms of our Materia Medica· προέλευση και παρασκευή από τον Clarke. Ιστορικό κείμενο από την κλασική materia medica (1828–1950). Δεν αποτελεί ιατρική συμβουλή ούτε ισχυρισμό ότι κάποιο φάρμακο δρα.
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7 λήμματα σε 6 βιβλία · συντομογραφίες: TUB

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Έρευνα (7)

Δημοσιεύσεις στο PubMed που αναφέρουν αυτό το φάρμακο μαζί με την ομοιοπαθητική, από τις νεότερες προς τις παλαιότερες.

Εμφάνιση 7 δημοσιεύσεων
  1. Individualized Homeopathic Medicines in the Management of Symptomatic Adenotonsillar Hypertrophy in Children: A Prospective Observational StudyPonnam HB, Varanasi R, Shil RC et al. · Homeopathy : the journal of the Faculty of Homeopathy · 2024 · Observational Study · doi
  2. Efficacy of Individualized Homeopathic Medicines in Treatment of Acne Vulgaris: A Double-Blind, Randomized, Placebo-Controlled TrialRai S, Gupta GN, Singh S et al. · Homeopathy : the journal of the Faculty of Homeopathy · 2022 · Randomized Controlled Trial · doi
  3. [Immunologische Ex-vivo-Untersuchung zur Wirkung potenzierter Substanzen bei parodontaler Entzündung unter Verwendung der Durchflusszytometrie]Gassmann G, Raak C, Schaupp F et al. · Complementary medicine research · 2019 · doi
  4. [Lymphocyte migration under exposure of homeopathic remedies for periodontal inflammation - a controlled pilot study]Gassmann G, Raak C, Büchel K et al. · Forschende Komplementarmedizin (2006) · 2015 · doi
  5. Giant tuberculin reaction associated with the homeopathic drug tuberculinum: a case reportSyrigou E, Gkiozos I, Dannos I et al. · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014 · Case Reports · doi
  6. Homeopathy in the treatment of tubercular lymphadenitis (TBLN)--an Indian experienceChand SK, Manchanda RK, Batra S et al. · Homeopathy : the journal of the Faculty of Homeopathy · 2011 · doi
  7. [Homeopathic treatment of adenoid vegetations. Results of a prospective, randomized double-blind study]Friese KH, Feuchter U, Moeller H · HNO · 1997 · Clinical Trial, Randomized Controlled Trial · doi

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