its chief center of action in the cerebrum, from which radiates its influence upon the entire organism. The brain and its membranes are involved in active congestion and inflammation. The sensorium is prominently affected, giving rise to delirium, illusions, hallucinations, mania, stupor, and insomnia. From this central point Belladonna acts as an irritant to the entire nervous system, producing congestion of the medulla oblongata and the spinal cord, and in consequence general hyperaesthesia of both sensory and motor nerves. The special senses become intensely acute, and at the same time perverted in function. The voluntary muscular system is involved in tetaniform convulsions, and sometimes clonic spasms, while the involuntary muscles are completely paralyzed, the sphincters being relaxed, and the iris dilated. On the skin and mucous membranes Belladonna shows its most important local action. The skin becomes intensely red and hot, presenting a smooth, shining, red surface, similar to that present in scarlet fever, and non vesicular erysipelas. The mucous membranes chiefly affected are those of the eyes, mouth, throat, and genito-urinary organs. The condition is similar to that found elsewhere, being an intense congestion going on to acute inflammation, involving also the submucous cellular tissue. Neither the digestive apparatus, nor the serous, osseous, or fibrous tissues are directly affected. But the glandular system is often involved in the characteristic congestion and inflammation of the drug, as are also the uterus and its appendages. The most characteristic expression of Belladonna is the flushed face, the throbbing carotids, the hard, full, and bounding pulse, and the wild delirium that ever attends its operations. Also the sudden appearance and disappearance of the symptoms. Characteristic symptoms.