1 . Prostration with nervous trembling particularly as a result of mental strain and loss of sleep. 2 . Patient ill-natured, angry, spiteful ; mentally and physically oversensitive. 3 . Cramps, convulsions and spasmodic affections generally. Clonic spasms beginning in fingers and toes. Epilepsies without any clear symptoms or where aura begins in knees and ascends. 4 . Paralysis especially of flexor muscles (extensors- Plumb.) ; also of tongue. 5 . Symptoms appear periodically and in groups. 6 , Cholera and choleric conditions ; body, cold, skin blue, collapse ; violent cramps abdomen and extremities. 7 . Repercussion of eruptions ; skin dusky, no rash but cerebral symptoms especially convulsions. 8 . Spasmodic respiratory troubles especially whooping cough ; long-continued paroxysms with difficult breathing, cyanosis and violent vomiting. 9 . Gurgling sound as of water poured out a bottle when drinking or coughing. 10 . Modalities ; < cold air, contact, before menstrual period nausea, vomiting and cough > drink of cold water ( Caust .). Note : Cuprum Aceticum is to be preferred where a more rapid action is desired. Keynote : Spasms.