Trembling ; twitching of various muscles. Convulsions. Constantly changing position, especially at night. Pains shift about, mostly in small spots ; pains are usually sharp, boring, or shooting, extending from within outward, sometimes in the opposite direction. Hysterical spasms. General aggravation from tea, coffee, tobacco and brandy ; after dinner, in the evening after lying down, and in the morning immediately after waking. Amelioration, from lying on the back, or on the painful portion ; and, in general, from change of position. Note : The general keynote of Ignatia is a condition of contrariness ; thus, a frontal headache is ameliorated by stooping : fever without thirst, etc.