Acts upon the medulla oblongata and the spinal nervous system, giving rise primarily to tetanic convulsions and dyspnoea, which may end in death. Secondarily, the entire nervous system becomes morbidly excited and sensitive, so that we find an intense acuteness of the nerves of sensation and of special sense, and an increased susceptibility to external impressions, both mental and physical. The coordination of functions is perverted, and at the same time we may find convulsive twitchings and spasms, or these alternating with torpor and depression. The leading expression of Ignatia is a finely sensitive mood, with tendency to sadness and silent grief, and continually brooding over imaginary troubles. Characteristic symptoms.