1 . Dark, phlegmatic subjects ; or women with red hair and freckled complexion, especially at climaxis ; also broken-down constitutions. 2 . Extreme alternations, mind and sensorium, (a) Mental activity with almost prophetic perception ; ecstasy ; loquacity with rapid change of subject especially when delirious ; hurry and flurry ; delusion of voices, etc. (b) Depression with anxiety ; patient silent, suspicious ; jealous ; weak memory, writing mistakes ; deranged time sense ; self-consciousness and selfishness. 3 . Hyperaesthesia of the senses ; of body surface ; nervous intolerance of touch , pressure and constriction , even of clothing, especially about throat and abdomen. 4 . Marked aggravation of all complaints from sleep ; patient sleeps into an attack ; sleep disturbed by frightful dreams, of dead and dying people, of suffocation, etc. 5 . All distressing symptoms are > onset of discharges ; e.g. at menstrual period always > during flow. 6 . Ailments left-sided or travel from left to right ; yet a special affinity for the appendix. 7 . Adynamic fevers with low, muttering delirium ; face purplish, besotted-looking, dropped jaw ; offensive breath ; tremors especially of the tongue which is protruded with difficulty ; haemorrhages of dark, decomposed blood. 8 . Septic states ; malignant ulcerations and suppuration ; with offensive discharges and bluish , livid appearance ; gangrene. 9 . Tremors, cramps, spasms and even convulsions. 10 . Modalities ; < heat especially heat of sun ; muggy weather ; must have air ; < spring ; throat symptoms < hot drinks and empty swallowing or liquids < than solids. Note. The great trio of remedies for women at climaxis : Lachesis, Sepia and Sulphur .